Regulation of chronic inflammatory and immune processes by extracellular vesicles

Paul D. Robbins; Akaitz Dorronsoro; Cori N. Booker

doi:10.1172/JCI81131

Regulation of chronic inflammatory and immune processes by extracellular vesicles

Paul D. Robbins
, Akaitz Dorronsoro
, Cori N. Booker

Research output: Contribution to journal › Review article › peer-review

254 Scopus citations

Abstract

Almost all cell types release extracellular vesicles (EVs), which are derived either from multivesicular bodies or from the plasma membrane. EVs contain a subset of proteins, lipids, and nucleic acids from the cell from which they are derived. EV factors, particularly small RNAs such as miRNAs, likely play important roles in cell-to-cell communication both locally and systemically. Most of the functions associated with EVs are in the regulation of immune responses to pathogens and cancer, as well as in regulating autoimmunity. This Review will focus on the different modes of immune regulation, both direct and indirect, by EVs. The therapeutic utility of EVs for the regulation of immune responses will also be discussed.

Original language	English (US)
Pages (from-to)	1173-1180
Number of pages	8
Journal	Journal of Clinical Investigation
Volume	126
Issue number	4
DOIs	https://doi.org/10.1172/JCI81131
State	Published - Apr 1 2016
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by the public health grants AG024827, AG03307, AR051456, and AG043376 from the National Institutes of Health; a program grant from the Juvenile Diabetes Research Foundation; and Aldabra Biosciences.

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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title = "Regulation of chronic inflammatory and immune processes by extracellular vesicles",

abstract = "Almost all cell types release extracellular vesicles (EVs), which are derived either from multivesicular bodies or from the plasma membrane. EVs contain a subset of proteins, lipids, and nucleic acids from the cell from which they are derived. EV factors, particularly small RNAs such as miRNAs, likely play important roles in cell-to-cell communication both locally and systemically. Most of the functions associated with EVs are in the regulation of immune responses to pathogens and cancer, as well as in regulating autoimmunity. This Review will focus on the different modes of immune regulation, both direct and indirect, by EVs. The therapeutic utility of EVs for the regulation of immune responses will also be discussed.",

author = "Robbins, \{Paul D.\} and Akaitz Dorronsoro and Booker, \{Cori N.\}",

note = "Funding Information: This work was supported by the public health grants AG024827, AG03307, AR051456, and AG043376 from the National Institutes of Health; a program grant from the Juvenile Diabetes Research Foundation; and Aldabra Biosciences.",

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AU - Dorronsoro, Akaitz

AU - Booker, Cori N.

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Regulation of chronic inflammatory and immune processes by extracellular vesicles

Abstract

Bibliographical note

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