Regulation of chronic inflammatory and immune processes by extracellular vesicles

Paul D. Robbins, Akaitz Dorronsoro, Cori N. Booker

Research output: Contribution to journalReview articlepeer-review

131 Scopus citations

Abstract

Almost all cell types release extracellular vesicles (EVs), which are derived either from multivesicular bodies or from the plasma membrane. EVs contain a subset of proteins, lipids, and nucleic acids from the cell from which they are derived. EV factors, particularly small RNAs such as miRNAs, likely play important roles in cell-to-cell communication both locally and systemically. Most of the functions associated with EVs are in the regulation of immune responses to pathogens and cancer, as well as in regulating autoimmunity. This Review will focus on the different modes of immune regulation, both direct and indirect, by EVs. The therapeutic utility of EVs for the regulation of immune responses will also be discussed.

Original languageEnglish (US)
Pages (from-to)1173-1180
Number of pages8
JournalJournal of Clinical Investigation
Volume126
Issue number4
DOIs
StatePublished - Apr 1 2016
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by the public health grants AG024827, AG03307, AR051456, and AG043376 from the National Institutes of Health; a program grant from the Juvenile Diabetes Research Foundation; and Aldabra Biosciences.

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