Regulation of blood flow in diabetic retinopathy

Amy R. Nippert, Eric A. Newman

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations

Abstract

Blood flow in the retina increases in response to light-evoked neuronal activity, ensuring that retinal neurons receive an adequate supply of oxygen and nutrients as metabolic demands vary. This response, termed "functional hyperemia,"is disrupted in diabetic retinopathy. The reduction in functional hyperemia may result in retinal hypoxia and contribute to the development of retinopathy. This review will discuss the neurovascular coupling signaling mechanisms that generate the functional hyperemia response in the retina, the changes to neurovascular coupling that occur in diabetic retinopathy, possible treatments for restoring functional hyperemia and retinal oxygen levels, and changes to functional hyperemia that occur in the diabetic brain.

Original languageEnglish (US)
Article numberE004
JournalVisual Neuroscience
DOIs
StatePublished - Jul 20 2020

Bibliographical note

Publisher Copyright:
© 2020 The Author(s). Published by Cambridge University Press.

Keywords

  • Diabetic retinopathy
  • Müller cells
  • blood flow
  • hypoxia
  • neurovascular coupling
  • neurovascular unit

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