Regular Wine Consumption in Chronic Heart Failure

Impact on Outcomes, Quality of Life, and Circulating Biomarkers

GISSI-HF Investigators

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background-Moderate, regular alcohol consumption is generally associated with a lower risk of cardiovascular events but data in patients with chronic heart failure are scarce. We evaluated the relations between wine consumption, health status, circulating biomarkers, and clinical outcomes in a large Italian population of patients with chronic heart failure enrolled in a multicenter clinical trial. Methods and Results-A brief questionnaire on dietary habits was administered at baseline to 6973 patients enrolled in the Gruppo Italiano per lo Studio della Sopravvivenza nell'Insufficienza Cardiaca-Heart Failure (GISSI-HF) trial. The relations between wine consumption, fatal and nonfatal clinical end points, quality of life, symptoms of depression, and circulating biomarkers of cardiac function and inflammation (in subsets of patients) were evaluated with simple and multivariable-adjusted statistical models. Almost 56% of the patients reported drinking at least 1 glass of wine per day. After adjustment, clinical outcomes were not significantly different in the predefined 4 groups of wine consumption. However, patients with more frequent wine consumption had a significantly better perception of health status (Kansas City Cardiomyopathy Questionnaire score, adjusted P<0.0001), less frequent symptoms of depression (Geriatric Depression Scale, adjusted P=0.01), and lower plasma levels of biomarkers of vascular inflammation (osteoprotegerin and C-terminal proendothelin-1, adjusted P<0.0001, and pentraxin-3, P=0.01) after adjusting for possible confounders. Conclusions-We show for the first time in a large cohort of patients with chronic heart failure that moderate wine consumption is associated with a better perceived and objective health status, lower prevalence of depression, and less vascular inflammation, but does not translate into more favorable clinical 4-year outcomes. Clinical Trial Registration-URL: http://www.clinicaltrials.gov. Unique identifier: NCT0033633.

Original languageEnglish (US)
Pages (from-to)428-437
Number of pages10
JournalCirculation: Heart Failure
Volume8
Issue number3
DOIs
StatePublished - May 4 2015

Fingerprint

Wine
Heart Failure
Biomarkers
Quality of Life
Depression
Health Status
Inflammation
Blood Vessels
Clinical Trials
Social Adjustment
Osteoprotegerin
Statistical Models
Feeding Behavior
Cardiomyopathies
Alcohol Drinking
Geriatrics
Drinking
Multicenter Studies
Glass
Population

Keywords

  • biological markers
  • quality of life
  • wine

Cite this

Regular Wine Consumption in Chronic Heart Failure : Impact on Outcomes, Quality of Life, and Circulating Biomarkers. / GISSI-HF Investigators.

In: Circulation: Heart Failure, Vol. 8, No. 3, 04.05.2015, p. 428-437.

Research output: Contribution to journalArticle

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abstract = "Background-Moderate, regular alcohol consumption is generally associated with a lower risk of cardiovascular events but data in patients with chronic heart failure are scarce. We evaluated the relations between wine consumption, health status, circulating biomarkers, and clinical outcomes in a large Italian population of patients with chronic heart failure enrolled in a multicenter clinical trial. Methods and Results-A brief questionnaire on dietary habits was administered at baseline to 6973 patients enrolled in the Gruppo Italiano per lo Studio della Sopravvivenza nell'Insufficienza Cardiaca-Heart Failure (GISSI-HF) trial. The relations between wine consumption, fatal and nonfatal clinical end points, quality of life, symptoms of depression, and circulating biomarkers of cardiac function and inflammation (in subsets of patients) were evaluated with simple and multivariable-adjusted statistical models. Almost 56{\%} of the patients reported drinking at least 1 glass of wine per day. After adjustment, clinical outcomes were not significantly different in the predefined 4 groups of wine consumption. However, patients with more frequent wine consumption had a significantly better perception of health status (Kansas City Cardiomyopathy Questionnaire score, adjusted P<0.0001), less frequent symptoms of depression (Geriatric Depression Scale, adjusted P=0.01), and lower plasma levels of biomarkers of vascular inflammation (osteoprotegerin and C-terminal proendothelin-1, adjusted P<0.0001, and pentraxin-3, P=0.01) after adjusting for possible confounders. Conclusions-We show for the first time in a large cohort of patients with chronic heart failure that moderate wine consumption is associated with a better perceived and objective health status, lower prevalence of depression, and less vascular inflammation, but does not translate into more favorable clinical 4-year outcomes. Clinical Trial Registration-URL: http://www.clinicaltrials.gov. Unique identifier: NCT0033633.",
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T1 - Regular Wine Consumption in Chronic Heart Failure

T2 - Impact on Outcomes, Quality of Life, and Circulating Biomarkers

AU - GISSI-HF Investigators

AU - Cosmi, Franco

AU - Di Giulio, Paola

AU - Masson, Serge

AU - Finzi, Andrea

AU - Marfisi, Rosa Maria

AU - Cosmi, Deborah

AU - Scarano, Marco

AU - Tognoni, Gianni

AU - Maggioni, Aldo P.

AU - Porcu, Maurizio

AU - Boni, Silvana

AU - Cutrupi, Giovanni

AU - Tavazzi, Luigi

AU - Latini, Roberto

AU - Barlera, S.

AU - Franzosi, M. G.

AU - Lucci, D.

AU - Marchioli, R.

AU - Nicolosi, G. L.

AU - Yusuf, S.

AU - Camerini, F.

AU - Cohn, Jay N

AU - Decarli, A.

AU - Pitt, B.

AU - Sleight, P.

AU - Poole-Wilson, P. A.

AU - Geraci, E.

AU - Scherillo, M.

AU - Fabbri, G.

AU - Bartolomei, B.

AU - Bertoli, D.

AU - Cobelli, F.

AU - Fresco, C.

AU - Ledda, A.

AU - Levantesi, G.

AU - Opasich, C.

AU - Rusconi, F.

AU - Sinagra, G.

AU - Turazza, F.

AU - Volpi, A.

AU - Ceseri, M.

AU - Alongi, G.

AU - Atzori, A.

AU - Bambi, F.

AU - Bastarolo, D.

AU - Bianchini, F.

AU - Cangioli, I.

AU - Canu, V.

AU - Caporusso, C.

AU - Cenni, G.

PY - 2015/5/4

Y1 - 2015/5/4

N2 - Background-Moderate, regular alcohol consumption is generally associated with a lower risk of cardiovascular events but data in patients with chronic heart failure are scarce. We evaluated the relations between wine consumption, health status, circulating biomarkers, and clinical outcomes in a large Italian population of patients with chronic heart failure enrolled in a multicenter clinical trial. Methods and Results-A brief questionnaire on dietary habits was administered at baseline to 6973 patients enrolled in the Gruppo Italiano per lo Studio della Sopravvivenza nell'Insufficienza Cardiaca-Heart Failure (GISSI-HF) trial. The relations between wine consumption, fatal and nonfatal clinical end points, quality of life, symptoms of depression, and circulating biomarkers of cardiac function and inflammation (in subsets of patients) were evaluated with simple and multivariable-adjusted statistical models. Almost 56% of the patients reported drinking at least 1 glass of wine per day. After adjustment, clinical outcomes were not significantly different in the predefined 4 groups of wine consumption. However, patients with more frequent wine consumption had a significantly better perception of health status (Kansas City Cardiomyopathy Questionnaire score, adjusted P<0.0001), less frequent symptoms of depression (Geriatric Depression Scale, adjusted P=0.01), and lower plasma levels of biomarkers of vascular inflammation (osteoprotegerin and C-terminal proendothelin-1, adjusted P<0.0001, and pentraxin-3, P=0.01) after adjusting for possible confounders. Conclusions-We show for the first time in a large cohort of patients with chronic heart failure that moderate wine consumption is associated with a better perceived and objective health status, lower prevalence of depression, and less vascular inflammation, but does not translate into more favorable clinical 4-year outcomes. Clinical Trial Registration-URL: http://www.clinicaltrials.gov. Unique identifier: NCT0033633.

AB - Background-Moderate, regular alcohol consumption is generally associated with a lower risk of cardiovascular events but data in patients with chronic heart failure are scarce. We evaluated the relations between wine consumption, health status, circulating biomarkers, and clinical outcomes in a large Italian population of patients with chronic heart failure enrolled in a multicenter clinical trial. Methods and Results-A brief questionnaire on dietary habits was administered at baseline to 6973 patients enrolled in the Gruppo Italiano per lo Studio della Sopravvivenza nell'Insufficienza Cardiaca-Heart Failure (GISSI-HF) trial. The relations between wine consumption, fatal and nonfatal clinical end points, quality of life, symptoms of depression, and circulating biomarkers of cardiac function and inflammation (in subsets of patients) were evaluated with simple and multivariable-adjusted statistical models. Almost 56% of the patients reported drinking at least 1 glass of wine per day. After adjustment, clinical outcomes were not significantly different in the predefined 4 groups of wine consumption. However, patients with more frequent wine consumption had a significantly better perception of health status (Kansas City Cardiomyopathy Questionnaire score, adjusted P<0.0001), less frequent symptoms of depression (Geriatric Depression Scale, adjusted P=0.01), and lower plasma levels of biomarkers of vascular inflammation (osteoprotegerin and C-terminal proendothelin-1, adjusted P<0.0001, and pentraxin-3, P=0.01) after adjusting for possible confounders. Conclusions-We show for the first time in a large cohort of patients with chronic heart failure that moderate wine consumption is associated with a better perceived and objective health status, lower prevalence of depression, and less vascular inflammation, but does not translate into more favorable clinical 4-year outcomes. Clinical Trial Registration-URL: http://www.clinicaltrials.gov. Unique identifier: NCT0033633.

KW - biological markers

KW - quality of life

KW - wine

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U2 - 10.1161/CIRCHEARTFAILURE.114.002091

DO - 10.1161/CIRCHEARTFAILURE.114.002091

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VL - 8

SP - 428

EP - 437

JO - Circulation: Heart Failure

JF - Circulation: Heart Failure

SN - 1941-3297

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