Regression in Early Childhood Development: An Unintended Outcome of Prolonged Hospitalization?

Claire Dahl, Maria Kroupina, Diana W Lone, Emily Greengard, Arif Somani

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


This brief review outlines a novel case study with targeted literature search. Patient X was a 21-month-old male who was receiving ongoing treatment for stage M MYCN-amplified high-risk neuroblastoma. Patient X's mother was considering refusal of further cancer-directed therapy because of the child's developmental regression noted during his prolonged hospitalization. Given the underlying malleability of the developing brain in early childhood, access to supportive services that facilitate ongoing neurodevelopment in hospitalized young children is of utmost importance; such services further reduce parental stress and likely enhances parental and medical team efficacy of care.

Original languageEnglish (US)
Pages (from-to)E795-E798
JournalJournal of pediatric hematology/oncology
Issue number3
StatePublished - Apr 1 2022

Bibliographical note

Publisher Copyright:
© 2022 Wolters Kluwer Health, Inc.


  • child development
  • developmental regression
  • early childhood mental health
  • pediatric hospitalization


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