Fusarium head blight (FHB) [caused by Fusarium graminearum Schwabe; telomorph Gibberella zeae (Schwein.) Petch] is a major disease of winter wheat (Triticum aestivum L.) in the US mid-Atlantic region. The objective of this research was to derive soft red winter wheat (SRWW) germplasm with enhanced FHB resistance for this region. MD01W233-06-1 (Reg. No. GP-857, PI No. 658682) is a soft red winter wheat (SRWW) (Triticum aestivum L.) germplasm line developed at the University of Maryland and released by the Maryland Agricultural Experiment Station in 2009. MD01W233-06-1 was selected from the cross 'McCormick'/'Choptank' made in 2001. McCormick and Choptank are SRWW cultivars adapted to the US mid-Atlantic region. MD01W233-06-1 was selected as an F3:5 line selection in Queenstown, MD in June 2006. MD01W233-06-1 has type II resistance to FHB that is different from that of 'Sumai 3'. Additionally, it has resistance to the Ug99 race of stem rust. These characteristics make this line a valuable contribution for breeding for enhanced FHB resistance in the US mid-Atlantic.