Regionally specific cortical thinning and gray matter abnormalities in the healthy relatives of schizophrenia patients

Vina M. Goghari, Kelly Rehm, Cameron S. Carter, Angus W. MacDonald

Research output: Contribution to journalArticlepeer-review

102 Scopus citations


Accumulated evidence suggests that schizophrenia is associated with subtle gray matter deficits throughout the cerebral cortex and regional cortical thinning. Although findings are not entirely consistent, healthy relatives of schizophrenia patients also show abnormalities in cortical gray matter volume, suggesting that this may be one aspect of an unexpressed genetic liability to the disorder. Cortical thickness and surface area are additional indicators of cortical cytoarchitectural integrity. To investigate the nature of cortical abnormalities in the healthy relatives of patients, this study used magnetic resonance imaging to evaluate gray matter volume, surface area, and thickness of 13 regions using an automated parcellation methodology. Compared with controls (n = 22), relatives (n = 19) had decreased volume and surface area in the right cingulate gyrus, a bilateral decrease in cingulate thickness, and decreased surface area in the superior temporal lobe. In addition, relatives had a subtle increase in gray matter volume and surface area in the left hemisphere, bilaterally in the parahippocampal gyri, and in the left middle temporal lobe. The results of this study suggest that the cortical regions most affected by the unexpressed genetic liability to schizophrenia may be the cingulate and temporal regions - regions associated with higher level cognitive, affective, and memory functions.

Original languageEnglish (US)
Pages (from-to)415-424
Number of pages10
JournalCerebral Cortex
Issue number2
StatePublished - Feb 2007

Bibliographical note

Funding Information:
Ms Goghari was supported by a PGS Master’s Award from the Natural Sciences and Engineering Research Council of Canada and by the Graduate Research Partnership Program, University of Minnesota. Additional support was provided by National Institute of Mental Health grant # MH45156 and the University of Minnesota. The authors gratefully acknowledge the assistance of the International Neuroimag-ing Consortium: Dr David Rottenberg, Kirt Schaper, Kristi Boesen, and Tim Jarvis; the University of Pittsburgh Medical Center, Department of Radiology; the Cognitive Control Neuroscience Laboratory; Western Psychiatric Institute and Clinic, University of Pittsburgh; and Theresa Becker, Jim Porter, Jill Stanton, Ryan Walter, Christopher Kallie, and Bruce Fischl. Preliminary data from this study were presented at the biennial meeting of the International Congress on Schizophrenia Research, Savannah Georgia, April 2--6, 2005, and at the 11th Annual Meeting of the Organization for Human Brain Mapping, Toronto, Ontario, June 12--16, 2005. Conflict of Interest: None declared.


  • Cingulate
  • Cortical thickness
  • Endophenotype
  • Family study
  • Magnetic resonance imaging
  • Temporal lobe


Dive into the research topics of 'Regionally specific cortical thinning and gray matter abnormalities in the healthy relatives of schizophrenia patients'. Together they form a unique fingerprint.

Cite this