TY - JOUR
T1 - Regional glucose uptake within hypoperfused swine myocardium as measured by positron emission tomography
AU - McFalls, Edward O
AU - Baldwin, Douglas
AU - Palmer, Brad
AU - Marx, David
AU - Jaimes, Diane
AU - Ward, Herbert B
PY - 1997
Y1 - 1997
N2 - Chronic myocardial ischemia and 2-[18F]fluoro-2-deoxy-D-glucose (FDG) uptake were studied with positron emission tomography in 12 swine instrumented with an external constrictor on the left anterior descending coronary artery (LAD). Serial changes in function (by echocardiography), blood flow (with H215O) and FDG were determined weekly. At 1 wk, function was normal and FDG uptake in the LAD and non-LAD regions was 0.43 ± 0.12 and 0.45 ± 0.11 μmol · min-1 · g-1, respectively (not significant). At ~5 wk, LAD wall thickening decreased to 18 ± 5 from 27 ± 8% (P < 0.05), whereas LAD and non-LAD blood flows were 0.68 ± 0.28 and 1.03 ± 0.25 ml · min-1 · g-1, respectively (P < 0.05). At that time, FDG uptake in LAD and non-LAD regions was 0.60 ± 0.43 and 0.49 ± 0.30 μmol · min-1 · g- 1, respectively (P < 0.05). By the use of transmural biopsies (n = 6), ATP and creatine phosphate in the LAD region were 3.62 ± 0.73 and 5.91 ± 1.44 μmol/g wet wt, respectively, and neither differed from values in remote regions. In this model of chronic ischemia, hypoperfused dysfunctional regions were characterized by enhanced glucose uptake and preserved bioenergetics. This supports the concept that the myocardium adapts to chronic ischemia.
AB - Chronic myocardial ischemia and 2-[18F]fluoro-2-deoxy-D-glucose (FDG) uptake were studied with positron emission tomography in 12 swine instrumented with an external constrictor on the left anterior descending coronary artery (LAD). Serial changes in function (by echocardiography), blood flow (with H215O) and FDG were determined weekly. At 1 wk, function was normal and FDG uptake in the LAD and non-LAD regions was 0.43 ± 0.12 and 0.45 ± 0.11 μmol · min-1 · g-1, respectively (not significant). At ~5 wk, LAD wall thickening decreased to 18 ± 5 from 27 ± 8% (P < 0.05), whereas LAD and non-LAD blood flows were 0.68 ± 0.28 and 1.03 ± 0.25 ml · min-1 · g-1, respectively (P < 0.05). At that time, FDG uptake in LAD and non-LAD regions was 0.60 ± 0.43 and 0.49 ± 0.30 μmol · min-1 · g- 1, respectively (P < 0.05). By the use of transmural biopsies (n = 6), ATP and creatine phosphate in the LAD region were 3.62 ± 0.73 and 5.91 ± 1.44 μmol/g wet wt, respectively, and neither differed from values in remote regions. In this model of chronic ischemia, hypoperfused dysfunctional regions were characterized by enhanced glucose uptake and preserved bioenergetics. This supports the concept that the myocardium adapts to chronic ischemia.
KW - fluorine-18 fluorodeoxyglucose uptake
KW - hibernation
KW - myocardial blood flow
KW - myocardial ischemia
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U2 - 10.1152/ajpheart.1997.272.1.h343
DO - 10.1152/ajpheart.1997.272.1.h343
M3 - Article
C2 - 9038955
AN - SCOPUS:33750702561
SN - 0363-6135
VL - 272
SP - H343-H349
JO - American Journal of Physiology - Heart and Circulatory Physiology
JF - American Journal of Physiology - Heart and Circulatory Physiology
IS - 1 41-1
ER -