Reflections on CD8 T-cell activation and memory

David Masopust, Rafi Ahmed

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations

Abstract

CD8 T cells contribute to clearance and long-term protection following acute infection with certain viruses, bacteria, and protozoa, and may play an important role in tumor immunity. Primary adaptive CD8 T-cell responses have been conceptually divided into four phases: activation, expansion, contraction, and memory. We summarize each phase of the response, and discuss recent advances in our understanding of the development and maintenance of CD8 T-cell memory.

Original languageEnglish (US)
Pages (from-to)151-160
Number of pages10
JournalImmunologic Research
Volume29
Issue number1-3
DOIs
StatePublished - Jul 7 2004

Keywords

  • CD8 T-cell differentiation
  • Cytotoxic T-cells
  • Immunological memory
  • T-cell immunity
  • Viral immunity

Fingerprint Dive into the research topics of 'Reflections on CD8 T-cell activation and memory'. Together they form a unique fingerprint.

Cite this