CD8 T cells contribute to clearance and long-term protection following acute infection with certain viruses, bacteria, and protozoa, and may play an important role in tumor immunity. Primary adaptive CD8 T-cell responses have been conceptually divided into four phases: activation, expansion, contraction, and memory. We summarize each phase of the response, and discuss recent advances in our understanding of the development and maintenance of CD8 T-cell memory.
Bibliographical noteFunding Information:
Supported by a Cancer Research Institute post doctoral fellowship (D.M.) and National Institutes of Health grant AI30048 and AI44644 (R.A.)
- CD8 T-cell differentiation
- Cytotoxic T-cells
- Immunological memory
- T-cell immunity
- Viral immunity