Reflections on CD8 T-cell activation and memory

David Masopust, Rafi Ahmed

Research output: Contribution to journalReview articlepeer-review

49 Scopus citations


CD8 T cells contribute to clearance and long-term protection following acute infection with certain viruses, bacteria, and protozoa, and may play an important role in tumor immunity. Primary adaptive CD8 T-cell responses have been conceptually divided into four phases: activation, expansion, contraction, and memory. We summarize each phase of the response, and discuss recent advances in our understanding of the development and maintenance of CD8 T-cell memory.

Original languageEnglish (US)
Pages (from-to)151-160
Number of pages10
JournalImmunologic Research
Issue number1-3
StatePublished - 2004

Bibliographical note

Funding Information:
Supported by a Cancer Research Institute post doctoral fellowship (D.M.) and National Institutes of Health grant AI30048 and AI44644 (R.A.)


  • CD8 T-cell differentiation
  • Cytotoxic T-cells
  • Immunological memory
  • T-cell immunity
  • Viral immunity


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