Reflections 1 year into the 21-center national institutes of health-funded wrist study: A primer on conducting a multicenter clinical trial

Kevin C. Chung, H. Myra Kim, Steven C. Haase, Jeffrey Lawton, Kagan Ozer, Jennifer F. Waljee, Kate Nellans, Sunitha Malay, Melissa J. Shauver, Tamara D. Rozental, Paul Appleton, Edward Rodriguez, Lindsay Herder, Katiri Wagner, Philip Blazar, Brandon Earp, W. Emerson Floyd, Katherine S. Pico, Marc J. Richards, David S. RuchSuzanne Finley, Loree K. Kalliainen, James W. Fletcher, Cherrie A. Heinrich, Christian M. Ward, Brian W. Hill, Brent Bamberger, Carla Robinson, Brandi Palmer, David Ring, Jesse B. Jupiter, Rajesh Reddy, David Dennison, Sanjeev Kakar, Alexander Shin, Tyson Scrabeck, Harry Hoyen, Kevin Malone, Sandeep Sebastin, Poh Ling Tay, Glenn Gaston, Benjamin Connell, Michael Neumeister, Nada N. Berry, Reuben A. Bueno, Mark McAndrew, Jennifer Koechle, Bertrand Perey, Mauri Zomar, Jennifer Moriatis Wolf, Craig M. Rodner, Mark Cote, Tod Clark, Thomas Lehman, Kathy Carl, David Bozentka, Scott Levin, David Steinberg, Annamarie Horan, Denise Knox, Warren Hammert, Allison W. McIntyre, Jeffrey B. Friedrich, Christopher H. Allan, Douglas P. Hanel, Jerry I. Huang, Jason H. Ko, Nicholas B. Vedder, David Boman, Claudette L. Cooper, Ruby Grewal, Joy MacDermid, Kate Kelly, Kristie Millman, Zhongyu Li, Andrew Koman, Beth Smith, Debra Bullard

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


The Wrist and Radius Injury Surgery Trial (WRIST) study group is a collaboration of 21 hand surgery centers in the United States, Canada, and Singapore, to showcase the interest and capability of hand surgeons to conduct a multicenter clinical trial. The WRIST study group was formed in response to the seminal systematic review by Margaliot et al and the Cochrane report that indicated marked deficiency in the quality of evidence in the distal radius fracture literature. Since the initial description of this fracture by Colles in 1814, over 2,000 studies have been published on this subject; yet, high-level studies based on the principles of evidence-based medicine are lacking. As we continue to embrace evidence-based medicine to raise the quality of research, the lessons learned during the organization and conduct of WRIST can serve as a template for others contemplating similar efforts. This article traces the course of WRIST by sharing the triumphs and, more important, the struggles faced in the first year of this study.

Original languageEnglish (US)
Pages (from-to)1194-1201
Number of pages8
JournalJournal of Hand Surgery
Issue number6
StatePublished - Jun 2013


  • Distal radius fracture
  • multicenter trials
  • randomized clinical trials


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