Reduction of immune activation with chloroquine therapy during chronic HIV infection

Shannon M. Murray, Carrie M. Down, David R. Boulware, William M. Stauffer, Winston P. Cavert, Timothy W. Schacker, Jason M. Brenchley, Daniel C. Douek

Research output: Contribution to journalArticlepeer-review

94 Scopus citations


Increased levels of activated T cells are a hallmark of the chronic stage of human immunodeficiency virus (HIV) infection and are highly correlated with HIV disease progression. We evaluated chloroquine (CQ) as a potential therapy to reduce immune activation during HIV infection. We found that the frequency of CD38+ HLA-DR+ CD8 T cells, as well as Ki-67 expression in CD8 and CD4 T cells, was significantly reduced during CQ treatment. Our data indicate that treatment with CQ reduces systemic T-cell immune activation and, thus, that its use may be beneficial for certain groups of HIV-infected individuals.

Original languageEnglish (US)
Pages (from-to)12082-12086
Number of pages5
JournalJournal of virology
Issue number22
StatePublished - Nov 2010

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