Reduction of immune activation with chloroquine therapy during chronic HIV infection

Shannon M. Murray; Carrie M. Down; David R. Boulware; William M. Stauffer; Winston P. Cavert; Timothy W. Schacker; Jason M. Brenchley; Daniel C. Douek

doi:10.1128/JVI.01466-10

Reduction of immune activation with chloroquine therapy during chronic HIV infection

Shannon M. Murray, Carrie M. Down, David R. Boulware, William M. Stauffer, Winston P. Cavert, Timothy W. Schacker, Jason M. Brenchley, Daniel C. Douek

Medicine - Infectious Disease and International

Research output: Contribution to journal › Article › peer-review

94 Scopus citations

Abstract

Increased levels of activated T cells are a hallmark of the chronic stage of human immunodeficiency virus (HIV) infection and are highly correlated with HIV disease progression. We evaluated chloroquine (CQ) as a potential therapy to reduce immune activation during HIV infection. We found that the frequency of CD38⁺ HLA-DR⁺ CD8 T cells, as well as Ki-67 expression in CD8 and CD4 T cells, was significantly reduced during CQ treatment. Our data indicate that treatment with CQ reduces systemic T-cell immune activation and, thus, that its use may be beneficial for certain groups of HIV-infected individuals.

Original language	English (US)
Pages (from-to)	12082-12086
Number of pages	5
Journal	Journal of virology
Volume	84
Issue number	22
DOIs	https://doi.org/10.1128/JVI.01466-10
State	Published - Nov 2010

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Reduction of immune activation with chloroquine therapy during chronic HIV infection. / Murray, Shannon M.; Down, Carrie M.; Boulware, David R.; Stauffer, William M.; Cavert, Winston P.; Schacker, Timothy W.; Brenchley, Jason M.; Douek, Daniel C.

In: Journal of virology, Vol. 84, No. 22, 11.2010, p. 12082-12086.

Research output: Contribution to journal › Article › peer-review

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abstract = "Increased levels of activated T cells are a hallmark of the chronic stage of human immunodeficiency virus (HIV) infection and are highly correlated with HIV disease progression. We evaluated chloroquine (CQ) as a potential therapy to reduce immune activation during HIV infection. We found that the frequency of CD38+ HLA-DR+ CD8 T cells, as well as Ki-67 expression in CD8 and CD4 T cells, was significantly reduced during CQ treatment. Our data indicate that treatment with CQ reduces systemic T-cell immune activation and, thus, that its use may be beneficial for certain groups of HIV-infected individuals.",

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