Reduction of Desipramine Cardiotoxicity and Prolongation of Survival in Rats With the Use of Polyclonal Drug-Specific Antibody Fab Fragments

Keyphrases

• Cardiotoxicity 100%
• Specific Antibodies 100%
• Desipramine 100%
• Antibody Fab Fragment 100%
• Sodium Bicarbonate 47%
• Sodium Chloride 17%
• QRS Interval 11%
• Tricyclic Antidepressants 11%
• Mechanical Ventilation 5%
• Cause of Death 5%
• Heart Rate 5%
• High Affinity 5%
• Clinical Treatment 5%
• Pressure Rate 5%
• Albumin 5%
• IV Infusion 5%
• Systolic Blood Pressure 5%
• Fab Fragment 5%
• Lethal Dose 5%
• Anesthetized Rats 5%
• Bovine Serum Albumin 5%
• Prolonged Survival 5%
• Cardiovascular Toxicity 5%
• Time Since Death 5%
• Molar Ratio 5%
• Interval Duration 5%
• Therapeutic Implications 5%
• Unbound Fraction 5%
• Drug Overdose 5%
• Interaction Protocols 5%
• Pharmacokinetic Activity 5%
• Concurrent Use 5%

Pharmacology, Toxicology and Pharmaceutical Science

• Cardiotoxicity 100%
• Immunoglobulin F(ab) Fragment 100%
• Desipramine 100%
• Rat 100%
• Dicarbonate 5%
• Tricyclic Antidepressant 5%
• Cardiovascular Toxicity 5%
• Tricyclic Antidepressant Overdose 5%
• Drug Overdose 5%
• Bovine Serum Albumin 5%
• Time of Death 5%
• Albumin 5%
• Pharmacokinetics 5%
• Antidote 5%