Reducing breast cancer recurrence with weight loss, a vanguard trial: The Exercise and Nutrition to Enhance Recovery and Good Health for You (ENERGY) Trial

Cheryl L. Rock, Tim E. Byers, Graham A. Colditz, Wendy Demark-Wahnefried, Patricia A. Ganz, Kathleen Y. Wolin, Anthony Elias, Helen Krontiras, Jingxia Liu, Michael Naughton, Bilgé Pakiz, Barbara A. Parker, Rebecca L. Sedjo, Holly Wyatt, Cheryl Rock, Bilge Pakiz, Barbara Parker, Chis Zoumas, Shirley Flatt, Hava Shoshana BarkaiDennis Heath, Lea Jacinto, Mila Pruitt, Patricia Ganz, Tim Byers, Rebecca Sedjo, James Hill, Jhenny Hernandez, Kim Gorman, Carmen Faust, Anna Van Pelt, Graham Colditz, Kathleen Wolin, Casey Fagin, Jennifer Tappenden, Sonya Izadi, Helen Krontiras, Cindy K Blair, Lahnor Powell, Laura Lee Goree, Karen Kubas

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

Breast cancer is the most common invasive cancer among women in developed countries. Obesity is a major risk factor for breast cancer recurrence and mortality in both pre- and postmenopausal women. Co-morbid medical conditions are common among breast cancer survivors. The Exercise and Nutrition to Enhance Recovery and Good Health for You (ENERGY) study is a 4-year randomized clinical trial of 693 overweight/obese women aged ≥21years diagnosed with any early stage breast cancer (stages I[≥1cm]-III) within the previous five years, designed to demonstrate the feasibility of achieving sustained weight loss and to examine the impact of weight loss on quality of life and co-morbidities, and to enable future exploration of biochemical mechanisms linking obesity to lower likelihood of disease-free survival. This trial is strategically designed as a vanguard for a fully-powered trial of women who will be evaluated for breast cancer recurrence and disease-free survival. Participants were recruited between 2010 and 2012 at four sites, had completed initial therapies, and had a body mass index between 25 and 45kg/m2. The intervention featured a group-based cognitive-behavioral weight loss program with telephone counseling and tailored newsletters to support initial weight loss and subsequent maintenance, with the goal of 7% weight loss at two years. This study has high potential to have a major impact on clinical management and outcomes after a breast cancer diagnosis. This trial initiates the effort to establish weight loss support for overweight or obese breast cancer survivors as a new standard of clinical care.

Original languageEnglish (US)
Pages (from-to)282-295
Number of pages14
JournalContemporary Clinical Trials
Volume34
Issue number2
DOIs
StatePublished - Mar 1 2013

Keywords

  • Breast cancer
  • Co-morbidities
  • Obesity
  • Quality of life
  • Weight reduction

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