Reduced vascular compliance as a marker for essential hypertension

Gary E. McVeigh, Durand E. Burns, Stanley M. Einkelstein, Kenneth M. McDonald, James E. Mock, William Eeske, Peter F. Carlyle, John Flack, Richard Grimm, Jay N. Cohn

Research output: Contribution to journalArticle

122 Citations (Scopus)

Abstract

In 38 patients with established essential hyperten­sion and 32 age-matched normotensive control sub­jects proximal and distal arterial compliance were determined by computer-based assessment of the diastolic decay of a brachial arterial tracing and a modified Windkessel model of the circulation. In the hypertensive subjects compared to the normo­tensive subjects mean arterial pressure was 25% higher (P <.001), systemic vascular resistance 23% higher (P <.01), proximal compliance 19% lower (P <.01), and distal compliance 72% lower (P <.001). The reduction in distal compliance was highly age- dependent. In the youngest age range (45 to 54 years) little overlap appeared between hypertensive and normotensive groups, whereas in the oldest subjects studied (65 to 75 years) distal compliance was comparably low in the two groups. Thus, distal vascular compliance provides a sensitive and spe­cific marker for the abnormal vasculature associated with hypertension and may be particularly useful in identifying the disease in young individuals with borderline blood pressure.

Original languageEnglish (US)
Pages (from-to)245-251
Number of pages7
JournalAmerican Journal of Hypertension
Volume4
Issue number3
DOIs
StatePublished - Jan 1 1991

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Compliance
Blood Vessels
Vascular Resistance
Essential Hypertension
Arterial Pressure
Arm
Blood Pressure
Hypertension

Keywords

  • Hypertension
  • Pulse contour analysis
  • Vascular compliance
  • Vascular resistance

Cite this

McVeigh, G. E., Burns, D. E., Einkelstein, S. M., McDonald, K. M., Mock, J. E., Eeske, W., ... Cohn, J. N. (1991). Reduced vascular compliance as a marker for essential hypertension. American Journal of Hypertension, 4(3), 245-251. https://doi.org/10.1093/ajh/4.3.245

Reduced vascular compliance as a marker for essential hypertension. / McVeigh, Gary E.; Burns, Durand E.; Einkelstein, Stanley M.; McDonald, Kenneth M.; Mock, James E.; Eeske, William; Carlyle, Peter F.; Flack, John; Grimm, Richard; Cohn, Jay N.

In: American Journal of Hypertension, Vol. 4, No. 3, 01.01.1991, p. 245-251.

Research output: Contribution to journalArticle

McVeigh, GE, Burns, DE, Einkelstein, SM, McDonald, KM, Mock, JE, Eeske, W, Carlyle, PF, Flack, J, Grimm, R & Cohn, JN 1991, 'Reduced vascular compliance as a marker for essential hypertension', American Journal of Hypertension, vol. 4, no. 3, pp. 245-251. https://doi.org/10.1093/ajh/4.3.245
McVeigh GE, Burns DE, Einkelstein SM, McDonald KM, Mock JE, Eeske W et al. Reduced vascular compliance as a marker for essential hypertension. American Journal of Hypertension. 1991 Jan 1;4(3):245-251. https://doi.org/10.1093/ajh/4.3.245
McVeigh, Gary E. ; Burns, Durand E. ; Einkelstein, Stanley M. ; McDonald, Kenneth M. ; Mock, James E. ; Eeske, William ; Carlyle, Peter F. ; Flack, John ; Grimm, Richard ; Cohn, Jay N. / Reduced vascular compliance as a marker for essential hypertension. In: American Journal of Hypertension. 1991 ; Vol. 4, No. 3. pp. 245-251.
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