Reduced subthalamic and subthalamic-cortical coherences associated with the therapeutic carryover effect of coordinated reset deep brain stimulation

Lvpiao Zheng; Ziling Luo; Biswaranjan Mohanty; Sana Amoozegar; Luke A. Johnson; Jerrold L. Vitek; Jing Wang

doi:10.1038/s41531-024-00797-w

Reduced subthalamic and subthalamic-cortical coherences associated with the therapeutic carryover effect of coordinated reset deep brain stimulation

Neurology

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Abstract

Coordinated reset deep brain stimulation (CR DBS), a promising treatment for Parkinson’s disease (PD), is hypothesized to desynchronize neuronal populations. However, little in vivo data probes this hypothesis. In a parkinsonian nonhuman primate, we found that subthalamic CR DBS suppressed subthalamic and cortical-subthalamic coherences in the beta band, correlating with motor improvements. Our results support the desynchronizing mechanism of CR DBS and propose potential biomarkers for closed-loop CR DBS.

Original language	English (US)
Article number	180
Journal	npj Parkinson's Disease
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41531-024-00797-w
State	Published - Dec 2024

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title = "Reduced subthalamic and subthalamic-cortical coherences associated with the therapeutic carryover effect of coordinated reset deep brain stimulation",

abstract = "Coordinated reset deep brain stimulation (CR DBS), a promising treatment for Parkinson{\textquoteright}s disease (PD), is hypothesized to desynchronize neuronal populations. However, little in vivo data probes this hypothesis. In a parkinsonian nonhuman primate, we found that subthalamic CR DBS suppressed subthalamic and cortical-subthalamic coherences in the beta band, correlating with motor improvements. Our results support the desynchronizing mechanism of CR DBS and propose potential biomarkers for closed-loop CR DBS.",

author = "Lvpiao Zheng and Ziling Luo and Biswaranjan Mohanty and Sana Amoozegar and Johnson, \{Luke A.\} and Vitek, \{Jerrold L.\} and Jing Wang",

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doi = "10.1038/s41531-024-00797-w",

language = "English (US)",

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AU - Zheng, Lvpiao

AU - Luo, Ziling

AU - Mohanty, Biswaranjan

AU - Amoozegar, Sana

AU - Johnson, Luke A.

AU - Vitek, Jerrold L.

AU - Wang, Jing

PY - 2024/12

Y1 - 2024/12

N2 - Coordinated reset deep brain stimulation (CR DBS), a promising treatment for Parkinson’s disease (PD), is hypothesized to desynchronize neuronal populations. However, little in vivo data probes this hypothesis. In a parkinsonian nonhuman primate, we found that subthalamic CR DBS suppressed subthalamic and cortical-subthalamic coherences in the beta band, correlating with motor improvements. Our results support the desynchronizing mechanism of CR DBS and propose potential biomarkers for closed-loop CR DBS.

AB - Coordinated reset deep brain stimulation (CR DBS), a promising treatment for Parkinson’s disease (PD), is hypothesized to desynchronize neuronal populations. However, little in vivo data probes this hypothesis. In a parkinsonian nonhuman primate, we found that subthalamic CR DBS suppressed subthalamic and cortical-subthalamic coherences in the beta band, correlating with motor improvements. Our results support the desynchronizing mechanism of CR DBS and propose potential biomarkers for closed-loop CR DBS.

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UR - https://www.scopus.com/pages/publications/85205376955#tab=citedBy

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VL - 10

JO - npj Parkinson's Disease

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ER -

Reduced subthalamic and subthalamic-cortical coherences associated with the therapeutic carryover effect of coordinated reset deep brain stimulation

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