Reduced subthalamic and subthalamic-cortical coherences associated with the therapeutic carryover effect of coordinated reset deep brain stimulation

Lvpiao Zheng, Ziling Luo, Biswaranjan Mohanty, Sana Amoozegar, Luke A. Johnson, Jerrold L. Vitek, Jing Wang

Research output: Contribution to journalArticlepeer-review

Abstract

Coordinated reset deep brain stimulation (CR DBS), a promising treatment for Parkinson’s disease (PD), is hypothesized to desynchronize neuronal populations. However, little in vivo data probes this hypothesis. In a parkinsonian nonhuman primate, we found that subthalamic CR DBS suppressed subthalamic and cortical-subthalamic coherences in the beta band, correlating with motor improvements. Our results support the desynchronizing mechanism of CR DBS and propose potential biomarkers for closed-loop CR DBS.

Original languageEnglish (US)
Article number180
Journalnpj Parkinson's Disease
Volume10
Issue number1
DOIs
StatePublished - Dec 2024

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© The Author(s) 2024.

PubMed: MeSH publication types

  • Journal Article

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