TY - JOUR
T1 - Reduced subthalamic and subthalamic-cortical coherences associated with the therapeutic carryover effect of coordinated reset deep brain stimulation
AU - Zheng, Lvpiao
AU - Luo, Ziling
AU - Mohanty, Biswaranjan
AU - Amoozegar, Sana
AU - Johnson, Luke A.
AU - Vitek, Jerrold L.
AU - Wang, Jing
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/12
Y1 - 2024/12
N2 - Coordinated reset deep brain stimulation (CR DBS), a promising treatment for Parkinson’s disease (PD), is hypothesized to desynchronize neuronal populations. However, little in vivo data probes this hypothesis. In a parkinsonian nonhuman primate, we found that subthalamic CR DBS suppressed subthalamic and cortical-subthalamic coherences in the beta band, correlating with motor improvements. Our results support the desynchronizing mechanism of CR DBS and propose potential biomarkers for closed-loop CR DBS.
AB - Coordinated reset deep brain stimulation (CR DBS), a promising treatment for Parkinson’s disease (PD), is hypothesized to desynchronize neuronal populations. However, little in vivo data probes this hypothesis. In a parkinsonian nonhuman primate, we found that subthalamic CR DBS suppressed subthalamic and cortical-subthalamic coherences in the beta band, correlating with motor improvements. Our results support the desynchronizing mechanism of CR DBS and propose potential biomarkers for closed-loop CR DBS.
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U2 - 10.1038/s41531-024-00797-w
DO - 10.1038/s41531-024-00797-w
M3 - Article
C2 - 39341818
AN - SCOPUS:85205376955
SN - 2373-8057
VL - 10
JO - npj Parkinson's Disease
JF - npj Parkinson's Disease
IS - 1
M1 - 180
ER -