Reduced prostaglandin synthesis by renal and aortic tissues from adult rats fed essential fatty acid-deficient diet after food deprivation

Hassan M. Sakr, Earl W Dunham

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Studies were conducted to determine the efficacy of a dietary technique for reducing prostaglandin (PG) synthesis in adult rats. Rats weighing 280-318 g were fed either essential fatty acid (EFA)-deficient or EFA-adequate diets for 10-17 days after a period of food deprivation. Synthesis of renal papillary PGE 2 and aortic PGI2 from endogenous precursor in vitro were estimated by liquid chromatographic and bioassay/radioimmunoassay techniques, respectively, as indices of the capacity of the technique to induce EFA deficiency. PGE synthesis and PGI2 synthesis by isolated tissues from rats fed the EFA-deficient diet were significantly decreased (ca. 50%) relative to control rats fed an EFA-adequate diet. Body and renal papillary weights were not significantly altered by the EFA-deficient diet.

Original languageEnglish (US)
Pages (from-to)183-192
Number of pages10
JournalProstaglandins, Leukotrienes and Medicine
Volume18
Issue number2
DOIs
StatePublished - May 1985

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