Reduced frontal white matter integrity in Early-Onset schizophrenia: A preliminary study

Sanjiv Kumra, Manzar Ashtari, Marjorie McMeniman, Joshua Vogel, Rachel Augustin, David E. Becker, Emilie Nakayama, Kunsang Gyato, John M. Kane, Kelvin Lim, Philip Szeszko

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124 Scopus citations


Background Research suggests that brain frontal white matter (WM) might be qualitatively altered in adolescents with early onset schizophrenia (EOS). Diffusion tensor imaging provides a relatively new approach for quantifying possible connectivity of WM in vivo. Methods Diffusion tensor imaging was used to examine the WM integrity of frontal regions at seven levels from 25 mm above to 5 mm below the anterior commissure-posterior commissure (AC-PC) plane. Three other regions were examined: the occipital region at the AC-PC plane and the genu and splenium of the corpus callosum. Fractional anisotropy was compared between 12 adolescents (nine male, 3 female) with EOS (onset of psychotic symptoms by age 18 years) and nine age-similar healthy comparison subjects (six male, 3 female). Results Adolescents with EOS had significantly reduced fractional anisotropy in the frontal WM at the AC-PC plane in both hemispheres and in the occipital WM at the AC-PC plane in the right hemisphere. Conclusions These preliminary data support a hypothesis that alterations in brain WM integrity occur in adolescents with EOS. Abnormalities found in this study were similar to those reported in adults with chronic schizophrenia. Additional studies are needed to assess whether there is progression of WM abnormalities in schizophrenia.

Original languageEnglish (US)
Pages (from-to)1138-1145
Number of pages8
JournalBiological psychiatry
Issue number12
StatePublished - Jun 15 2004

Bibliographical note

Funding Information:
This work was supported by National Institute of Mental Health grants MH-60221 (JMK), MH-64556 (SK), and MH-01990 (PS); a National Alliance for Research on Schizophrenia and Depression Young Investigator Award (SK); North Shore-Long Island Jewish Research Institute General Clinical Research Center Grant M01 RR018535; Center for Advanced Magnetic Resonance Technology at Stanford P41RR008784; and a grant from the North Shore-Long Island Jewish Hospital Research Institute.


  • Schizophrenia
  • adolescents
  • diffusion tensor imaging
  • early-onset
  • magnetic resonance imaging
  • white matter


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