Reduced atrial natriuretic factor after ligation of the left coronary artery in rats

Tom S. Rector, Peter F. Carlyle, Jay N Cohn

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The diuretic-natriuretic responses of eight assay rats to extracts of atrial tissue obtained 3 months after left coronary ligation were less than the responses to extracts of tissue from sham-operated controls. The mean difference in diuresis (sham-operated response minus ligated response) was 370 (range 22 to 656) μl/20 minutes (p < 0.01) and in natriuresis 56 (range -92 to 222) μEq/20 minutes (p = 0.19). The differences in diuretic responses to these extracts was directly related to the severity of elevation of left ventricular end-diastolic pressure in these rats (r = -0.82, p = 0.01). These results in a model with varying degrees of left ventricular dysfunction suggest that myocardial damage is associated with a chronic decrease in atrial natriuretic factor. Reduced circulating atrial natriuretic factor therefore could contribute to the previously observed impaired ability of coronary ligated rats to excrete a saline load and to the sodium retention observed in clinical heart failure. Conclusive evidence will depend on the development of techniques to measure plasma levels of this hormone.

Original languageEnglish (US)
Pages (from-to)1197-1199
Number of pages3
JournalAmerican Heart Journal
Issue number6
StatePublished - Dec 1985


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