Reduced apoprotein B and increased lipoprotein turnover in cholesterol-fed rabbits after partial ileal bypass

C. R. Sirtori, G. C. Ghiselli, A. L. Catapano, M. R. Lovati, C. Fragiacomo, U. Fox, G. Majone, H. Buchwald

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7 Scopus citations

Abstract

Plasma lipid and lipoprotein levels and composition of the very low-, low-, and high-density lipoproteins (VLDL, LDL, HDL) were studied in white New Zealand rabbits in the control state, 8 weeks after initiation of a 2% cholesterol-enriched diet, and sequentially for 16 weeks following a partial ileal bypass (PIB) procedure. Turnover and aortic uptake of 125I-labeled VLDL, obtained from the rabbits before and 16 weeks after PIB, were also analyzed. A significant reduction of plasma cholesterol from the postdiet levels to well below the prediet mean, despite continuation of the high cholesterol diet, followed PIB. A very early reduction of the apoprotein B percentage content in both VLDL and LDL was observed after the procedure, even when a relative cholesterol ester enrichment of these lipoproteins was still present. HDL cholesterol levels were somewhat lowered by the experimental diet and further reduced after PIB. 125I-labeled VLDL after PIB showed a reduced arterial uptake, as compared to the same lipoproteins from animals before PIB. These findings may provide an interpretation for the decreased atherogenesis after PIB.

Original languageEnglish (US)
Pages (from-to)243-251
Number of pages9
JournalSurgery
Volume89
Issue number2
StatePublished - 1981

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