Reduced alcohol use in patients prescribed pioglitazone

Eric Dieperink, Peter Hauser, Kathryn Dockter, Juan Miranda, Meredith Evenson, Paul Thuras

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND AND OBJECTIVES: Alcohol use disorder (AUD) is common and causes significant morbidity and mortality. Currently approved medications are moderately effective. Novel medications are needed to address AUD. Preliminary data suggests pioglitazone may reduce alcohol use.

METHODS: Veterans seen at the Minneapolis VA Health Care System, who were prescribed pioglitazone for diabetes between October 1, 2015 and September 30, 2016, were identified using a national VA database (N = 49). Further chart review was performed to identify all Alcohol Use Disorder Identification Test-Consumption (AUDIT-C) scores prior to starting pioglitazone. Hierarchical Linear models were used to compare all AUDIT-C scores on and off pioglitazone and compare the change in AUDIT-C scores over time before and during pioglitazone was prescribed. AUDIT-C scores were nested within subject with fixed effects for pioglitazone and random intercept and slope for time.

RESULTS: Forty-nine patients were prescribed pioglitazone and had AUDIT-C scores of 3 or more. The estimated mean AUDIT-C score prior to receiving pioglitazone was 3.98 (95% confidence interval [CI]: 3.51-4.44) and this was reduced to 2.89 (95% CI: 2.46-3.32), reflecting a significant change F(1, 323) = 43.3, p < .001 in the score. The primary reduction occurred within the first year of the pioglitazone prescription. This effect remained significant after controlling for age.

CONCLUSION AND SCIENTIFIC SIGNIFICANCE: This is the first study of pioglitazone used in a clinical sample focused on alcohol use outcome. The data show that pioglitazone may reduce alcohol use in patients with heavy drinking. Clinical trials of pioglitazone are warranted in patients with AUD.

Original languageEnglish (US)
Pages (from-to)570-577
Number of pages8
JournalAmerican Journal on Addictions
Volume30
Issue number6
Early online dateAug 19 2021
DOIs
StatePublished - Nov 2021

Bibliographical note

Funding Information:
This work was supported by the US Department of Veterans Affairs Clinical Sciences Research and Development Merit review project # NURA‐015‐18S (ED).

Funding Information:
This work was supported by the US Department of Veterans Affairs Clinical Sciences Research and Development Merit review project # NURA-015-18S (ED).

Publisher Copyright:
Published 2021. This article is a U.S. Government work and is in the public domain in the USA.

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