Redox signaling in oxygen sensing by vessels

Andrea Olschewski; E. Kenneth Weir

doi:10.1007/978-0-387-47530-1_10

Redox signaling in oxygen sensing by vessels

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Oxidant production and regulation is becoming increasingly important in the study of vascular signaling mechanism.Alarge number of studies during the last 50 years have provided evidence that vascular preparations show alterations in contractile function over a wide range of O₂ tensions that are observed in physiological systems. Based on observations that reactive oxygen species were vasoactive and appeared to have distinct signaling mechanisms, itwas suggested that these species could function in vascular O₂ sensing mechanisms that mediated responses to acute changes in pO ₂.^1,2

Original language	English (US)
Title of host publication	Molecular Sensors for Cardiovascular Homeostasis
Publisher	Springer US
Pages	171-188
Number of pages	18
ISBN (Print)	0387475281, 9780387475288
DOIs	https://doi.org/10.1007/978-0-387-47530-1_10
State	Published - 2007
Externally published	Yes

Bibliographical note

Funding Information:
E. Kenneth Weir is supported by general medical research funds from the US Department of Veterans Affairs and NIH (ROI-HL 65322-01A1). The authors appreciate the intellectual contributions of Stephen L. Archer, MD and Douglas A. Peterson, MD, PhD to the concepts developed in this paper.

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abstract = "Oxidant production and regulation is becoming increasingly important in the study of vascular signaling mechanism.Alarge number of studies during the last 50 years have provided evidence that vascular preparations show alterations in contractile function over a wide range of O2 tensions that are observed in physiological systems. Based on observations that reactive oxygen species were vasoactive and appeared to have distinct signaling mechanisms, itwas suggested that these species could function in vascular O2 sensing mechanisms that mediated responses to acute changes in pO 2.1,2",

author = "Andrea Olschewski and Weir, {E. Kenneth}",

note = "Funding Information: E. Kenneth Weir is supported by general medical research funds from the US Department of Veterans Affairs and NIH (ROI-HL 65322-01A1). The authors appreciate the intellectual contributions of Stephen L. Archer, MD and Douglas A. Peterson, MD, PhD to the concepts developed in this paper.",

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AU - Weir, E. Kenneth

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Y1 - 2007

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BT - Molecular Sensors for Cardiovascular Homeostasis

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ER -

Redox signaling in oxygen sensing by vessels

Abstract

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