TY - JOUR
T1 - Redox signaling and sarcopenia
T2 - Searching for the primary suspect
AU - Foreman, Nicholas A.
AU - Hesse, Anton S.
AU - Ji, Li Li
N1 - Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/8/22
Y1 - 2021/8/22
N2 - Sarcopenia, the age-related decline in muscle mass and function, derives from multiple eti-ological mechanisms. Accumulative research suggests that reactive oxygen species (ROS) generation plays a critical role in the development of this pathophysiological disorder. In this communication, we review the various signaling pathways that control muscle metabolic and functional integrity such as protein turnover, cell death and regeneration, inflammation, organismic damage, and metabolic functions. Although no single pathway can be identified as the most crucial factor that causes sar-copenia, age-associated dysregulation of redox signaling appears to underlie many deteriorations at physiological, subcellular, and molecular levels. Furthermore, discord of mitochondrial homeostasis with aging affects most observed problems and requires our attention. The search for the primary suspect of the fundamental mechanism for sarcopenia will likely take more intense research for the secret of this health hazard to the elderly to be unlocked.
AB - Sarcopenia, the age-related decline in muscle mass and function, derives from multiple eti-ological mechanisms. Accumulative research suggests that reactive oxygen species (ROS) generation plays a critical role in the development of this pathophysiological disorder. In this communication, we review the various signaling pathways that control muscle metabolic and functional integrity such as protein turnover, cell death and regeneration, inflammation, organismic damage, and metabolic functions. Although no single pathway can be identified as the most crucial factor that causes sar-copenia, age-associated dysregulation of redox signaling appears to underlie many deteriorations at physiological, subcellular, and molecular levels. Furthermore, discord of mitochondrial homeostasis with aging affects most observed problems and requires our attention. The search for the primary suspect of the fundamental mechanism for sarcopenia will likely take more intense research for the secret of this health hazard to the elderly to be unlocked.
KW - Aging
KW - Mitochondria
KW - Peroxiredoxin
KW - Redox signaling
KW - Sarcopenia
KW - Skeletal muscle
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U2 - 10.3390/ijms22169045
DO - 10.3390/ijms22169045
M3 - Review article
C2 - 34445751
AN - SCOPUS:85113167619
SN - 1661-6596
VL - 22
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 16
M1 - 9045
ER -