Redox signaling and sarcopenia: Searching for the primary suspect

Nicholas A. Foreman, Anton S. Hesse, Li Li Ji

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations


Sarcopenia, the age-related decline in muscle mass and function, derives from multiple eti-ological mechanisms. Accumulative research suggests that reactive oxygen species (ROS) generation plays a critical role in the development of this pathophysiological disorder. In this communication, we review the various signaling pathways that control muscle metabolic and functional integrity such as protein turnover, cell death and regeneration, inflammation, organismic damage, and metabolic functions. Although no single pathway can be identified as the most crucial factor that causes sar-copenia, age-associated dysregulation of redox signaling appears to underlie many deteriorations at physiological, subcellular, and molecular levels. Furthermore, discord of mitochondrial homeostasis with aging affects most observed problems and requires our attention. The search for the primary suspect of the fundamental mechanism for sarcopenia will likely take more intense research for the secret of this health hazard to the elderly to be unlocked.

Original languageEnglish (US)
Article number9045
JournalInternational journal of molecular sciences
Issue number16
StatePublished - Aug 22 2021

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.


  • Aging
  • Mitochondria
  • Peroxiredoxin
  • Redox signaling
  • Sarcopenia
  • Skeletal muscle


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