Redesigning secondary structure to invert coenzyme specificity in isopropylmalate dehydrogenase

Biochemistry, Genetics and Molecular Biology

• Amino Acid Substitution 33%
• Amino Acids 66%
• Coenzyme 100%
• Crystal Structure 33%
• Dehydrogenase 100%
• Enzyme 66%
• Molecular Model 33%
• Nicotinamide Adenine Dinucleotide Phosphate 33%
• Oxidoreductase 100%
• Protein Engineering 33%
• Protein Secondary Structure 100%
• Protein Structure 33%
• Protein Tertiary Structure 33%
• Site-Directed Mutagenesis 33%
• Thermus thermophilus 33%
• Wild Type 33%

Keyphrases

• 3-Isopropylmalate Dehydrogenase 100%
• Amino Acid Substitution 33%
• Amino Acids 33%
• Changes in Function 66%
• Enzyme Selectivity 100%
• Helix 33%
• Key Amino Acids 33%
• Molecular Modeling 33%
• Protein Engineering 33%
• Protein Folding 33%
• Protein Structure 33%
• Rational Engineering 66%
• Secondary Structure 100%
• Site-directed mutagenesis 33%
• Structure Modeling 33%
• Thermus Thermophilus 33%
• X-ray Crystal Structure 33%