Recurrent syncope as a chronic disease - Preliminary validation of a disease-specific measure of functional impairment

Mark Linzer, Deborah T. Gold, Michele Pontinen, George W. Divine, Alonzo Felder, W. Blair Brooks

Research output: Contribution to journalArticlepeer-review

67 Scopus citations


Background: A disease-specific measure of functional health in syncope would provide an important outcome measure for use either in clinical trials or in the clinical management of patients with recurrent syncope. Methods arid Measurements: In a previous study the authors used formal functional status measures to determine physical and psycho-social impairment in recurrent syncope. This study provides a preliminary assessment of a disease-specific measure of function. The measure was pilot tested on 84 subjects, and validated in a separate cohort of 49 patients. The measure consists of 1) an 11-question matrix of yes/no questions, assessing the ways that syncope interferes with a patient's life (the result is expressed as a proportion of the total number of ways that syncope might interfere and is called the Impairment Score), and 2) three Likert-scale questions that assess the patient's fear and worry about syncope. Correlations were obtained between scores on the disease-specific measure and other measures of functional health. Results: Among the 49 patients in the test cohort, final scores on the disease-specific measure correlated with both physical and psycho-social dimension scores on a measure of functional status, the Sickness Impact Profile (r=0.35-0.36, p=0.01), and with five of ten subscale scores on a measure of psychological distress, the Symptom Checklist 90-R (r=0.30-0.43, p=0.004-0.02). Conclusions: This new disease-specific quality-of-life measure in syncope measures both physical and psychosocial components of impairment and could be a valuable adjunct in measuring outcomes in syncope patients.

Original languageEnglish (US)
Pages (from-to)181-186
Number of pages6
JournalJournal of general internal medicine
Issue number4
StatePublished - Apr 1994


  • clinical epidemiology
  • functional status
  • outcome measures
  • syncope

Fingerprint Dive into the research topics of 'Recurrent syncope as a chronic disease - Preliminary validation of a disease-specific measure of functional impairment'. Together they form a unique fingerprint.

Cite this