Recurrent Renal Disease After Transplantation

Shanthi S. Balani, Paul R. Brakeman

Research output: Chapter in Book/Report/Conference proceedingChapter


In the pediatric population, primary glomerulonephritis diseases, including focal segmental glomerulosclerosis (FSGS), IgA nephropathy (IgAN), and membranoproliferative GN (MPGN), are the second most common cause of end-stage renal disease (ESRD), representing 21.1% of all pediatric ESRD patients [1]. In addition, secondary glomerular diseases, including systemic lupus erythematosus (SLE), ANCA-associated vasculitis (AAV), and complement-mediated glomerular disease, are the fourth leading cause of ESRD, representing 8.0% of pediatric patients with ESRD [1]. These conditions can recur after transplantation with varying effects on the allograft and long-term transplant outcomes (Table 1). The goal of this chapter is to describe the epidemiology, pathophysiology, treatment options, and allograft outcomes for patients in whom these conditions recur after transplant.

Original languageEnglish (US)
Title of host publicationPediatric Solid Organ Transplantation
Subtitle of host publicationA Practical Handbook
PublisherSpringer Nature
Number of pages23
ISBN (Electronic)9789811969096
ISBN (Print)9789811969089
StatePublished - Jan 1 2023

Bibliographical note

Publisher Copyright:
© Springer Nature Singapore Pte Ltd. 2023.


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