Recurrent mutations in the stress regulator Cap1 reveal a trade-off between azole resistance and oxidative stress response in Candida albicans

Keyphrases

• Candida Albicans (C. albicans) 100%
• Oxidative Stress Response 100%
• Recurrent mutation 100%
• Azole Resistance 100%
• Stress Regulator 100%
• Nonsense mutation 75%
• Azoles 50%
• Fluconazole 50%
• C-terminal Truncation 50%
• Transcription Factor 25%
• Adaptation 25%
• Minimum Inhibitory Concentration 25%
• Murine Model 25%
• Drug Resistance 25%
• Stress Response 25%
• Drug Resistance Reversal 25%
• Missense mutation 25%
• Life-threatening 25%
• Clinical Setting 25%
• Bloodstream Infection 25%
• Fungal Infection 25%
• Putative Drug Targets 25%
• Reactive Oxygen Species 25%
• Point mutation 25%
• Candidiasis 25%
• DNA-binding Domain 25%
• Nuclear Export Signal 25%
• Fitness Advantage 25%
• Nuclear Retention 25%
• Drug Transport 25%
• Fungicidal Effect 25%
• Therapeutic Vulnerability 25%
• C. Albicans Infection 25%

Immunology and Microbiology

• Candida Albicans 100%
• Oxidative Stress 100%
• Infectious Disease 75%
• Carboxy Terminal Sequence 75%
• Nonsense Mutation 75%
• Infection 75%
• Drug Resistance 50%
• In Vitro 50%
• Minimum Inhibitory Concentration 25%
• Point Mutation 25%
• DNA Binding 25%
• Missense Mutation 25%
• Nuclear Export Signal 25%
• Drug Transport 25%
• Transcription Factors 25%
• Dioxygen 25%
• Therapeutic Target 25%

Biochemistry, Genetics and Molecular Biology

• Oxidative Stress 100%
• Candida Albicans 100%
• CAP1 100%
• Nonsense Mutation 42%
• C-Terminus 42%
• Drug Resistance 28%
• DNA-binding Domain 14%
• Missense Mutation 14%
• Point Mutation 14%
• Nuclear Export Signal 14%
• Drug Transport 14%
• Transcription Factors 14%
• Minimum Inhibitory Concentration 14%
• Bloodstream Infection 14%