Recurrent acute pancreatitis: International state-of-the-science conference with recommendations

Nalini M. Guda, Venkata Muddana, David C. Whitcomb, Philippe Levy, Pramod Garg, Gregory Cote, Aliye Uc, Shyam Varadarajulu, Santhi S. Vege, Suresh T. Chari, Chris E. Forsmark, Dhiraj Yadav, D. Nageshwar Reddy, Scott Tenner, Colin D. Johnson, Fatih Akisik, Ashok K. Saluja, Markus M. Lerch, James S Mallery, Martin L Freeman

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Recurrent acute pancreatitis (RAP) is a clinically significant problem globally. The etiology remains unclear in approximately 10% to 15% of patients despite a thorough workup. Data on natural history and efficacy of treatments are limited. We aimed to establish criteria for diagnosis, evaluate the causative factors, and arrive at a consensus on the appropriate workup and management of patients with RAP. The organizing committee was formed, and a set of questions was developed based on the current evidence, controversies, and topics that needed further research. After a vetting process, these topics were assigned to a group of experts from around the world with special interest in RAP. Data were presented as part of a workshop on RAP organized as a part of the annual meeting of the America Pancreatic Association. Pretest and Posttest questions were administered, and the responses were tabulated by the current Grades of Recommendation Assessment, Development and Evaluation system. The consensus guidelines were established in the format of a diagnostic algorithm. Several deficiencies were identified with respect to data on etiology, treatment efficacies, and areas that need immediate research.

Original languageEnglish (US)
Pages (from-to)653-666
Number of pages14
Issue number6
StatePublished - Jul 1 2018

Bibliographical note

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© 2018 Wolters Kluwer Health, Inc.


  • diagnostic algorithm
  • etiology
  • recurrent acute pancreatitis
  • treatment efficacies
  • workup


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