Abstract
Reduced glutathione (GSH), a potential factor in the chronicity of human otitis media, was tested to determine its potency in the recurrence of antigen-induced otitis media in chinchillas sensitized with human serum albumin (HSA). GSH instillation into the healing middle ear bulla reproduced a level of otitis media similar to the original antigen-induced otitis media with cellular involvement occurring earlier, according to cytologic analyses. This study indicates that GSH is probably a factor in recurrent antigen-induced otitis media, controlling the balance between thiol proteases and thiol protease inhibitors during middle ear inflammation.
Original language | English (US) |
---|---|
Pages (from-to) | 111-116 |
Number of pages | 6 |
Journal | American Journal of Otolaryngology - Head and Neck Medicine and Surgery |
Volume | 9 |
Issue number | 3 |
DOIs | |
State | Published - 1988 |
Bibliographical note
Funding Information:Supported by the National Institute of Neurological and CommunicationD isorders and Stroke grant no. NS-14538 for the Otitis Media Pathogenesis Research Program.
Keywords
- antigen-induced otitis media
- glutathlone recurrence