Recurrence of antigen-inducedotitis media by thiol compound

Yukiyoshi Hamaguchi, Steven S Juhn, Yasuo Sakakura

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Reduced glutathione (GSH), a potential factor in the chronicity of human otitis media, was tested to determine its potency in the recurrence of antigen-induced otitis media in chinchillas sensitized with human serum albumin (HSA). GSH instillation into the healing middle ear bulla reproduced a level of otitis media similar to the original antigen-induced otitis media with cellular involvement occurring earlier, according to cytologic analyses. This study indicates that GSH is probably a factor in recurrent antigen-induced otitis media, controlling the balance between thiol proteases and thiol protease inhibitors during middle ear inflammation.

Original languageEnglish (US)
Pages (from-to)111-116
Number of pages6
JournalAmerican Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume9
Issue number3
DOIs
StatePublished - 1988

Bibliographical note

Funding Information:
Supported by the National Institute of Neurological and CommunicationD isorders and Stroke grant no. NS-14538 for the Otitis Media Pathogenesis Research Program.

Keywords

  • antigen-induced otitis media
  • glutathlone recurrence

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