Recruitment of Th1 effector cells in human tuberculosis: Hierarchy of chemokine receptor(s) and their ligands

Pradip K. Saha, Prabhat K. Sharma, Surendra K. Sharma, Amar Singh, Dipendra K. Mitra

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Selective recruitment of IFN-γ biased Th1 effector cells at the pathologic site(s) determines the local immunity of tuberculosis (TB). We observed the enrichment of CXCR3, CCR5 and CD11ahigh T cells in the peripheral blood, pleural fluid and bronchoalveolar lavage of TB pleural effusion (TB-PE) and miliary tuberculosis (MTB) patients respectively. CXCR3+CCR5+ T cells were significantly high at the local disease site(s) in both the forms of TB and their frequency was highest among activated lymphocytes in TB-PE. Interestingly, all CCR5+ cells were invariably positive for CXCR3 but all CXCR3+ cells did not co-express CCR5 in pleural fluid whereas the situation was reverse in bronchoalveolar lavage. These CXCR3+CCR5+ cells dominantly produced IFN-γ in response to Mycobacterium tuberculosis antigen. In vitro chemotaxis assay indicates dominant role of RANTES and IP-10 in the selective recruitment of CXCR3+CCR5+cells at the tubercular pathologic sites.

Original languageEnglish (US)
Pages (from-to)43-51
Number of pages9
JournalCytokine
Volume63
Issue number1
DOIs
StatePublished - Jul 1 2013

Keywords

  • Chemokines
  • Miliary tuberculosis
  • T cells
  • Tuberculosis

Fingerprint Dive into the research topics of 'Recruitment of Th1 effector cells in human tuberculosis: Hierarchy of chemokine receptor(s) and their ligands'. Together they form a unique fingerprint.

Cite this