Recruitment and disruption of ventral pallidal cue encoding during alcohol seeking

David J. Ottenheimer, Karen Wang, Alexandria Haimbaugh, Patricia H. Janak, Jocelyn M. Richard

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

A critical area of inquiry in the neurobiology of alcohol abuse is the mechanism by which cues gain the ability to elicit alcohol use. Previously, we found that cue-evoked activity in rat ventral pallidum robustly encodes the value of sucrose cues trained under both Pavlovian and instrumental contingencies, despite a stronger relationship between cue-evoked activity and behavioral latency after instrumental training (Richard et al., 2018, Elife, 7, e33107). Here, we assessed: (a) ventral pallidal representations of Pavlovian versus instrumental cues trained with alcohol reward, and (b) the impact of non-associative alcohol exposure on ventral pallidal representations of sucrose cues. Decoding of cue identity based on ventral pallidum firing was blunted for the Pavlovian alcohol cue in comparison to both the instrumental cue trained with alcohol and either cue type trained with sucrose. Further, non-associative alcohol exposure had opposing effects on ventral pallidal encoding of sucrose cues trained on instrumental versus Pavlovian associations, enhancing decoding accuracy for an instrumental discriminative stimulus and reducing decoding accuracy for a Pavlovian conditioned stimulus. These findings suggest that alcohol exposure can drive biased engagement of specific reward-related signals in the ventral pallidum.

Original languageEnglish (US)
Pages (from-to)3428-3444
Number of pages17
JournalEuropean Journal of Neuroscience
Volume50
Issue number9
DOIs
StatePublished - Nov 1 2019

Bibliographical note

Funding Information:
This work was supported by National Institutes of Health grants F32 AA022290 (JMR), K99/R00 AA025384 (JMR), R01 AA014925 (PHJ) and R01 AA026306 (PHJ), by a NARSAD Young Investigator Award (JMR), and by the National Science Foundation Graduate Research Fellowship under Grant No. DGE-1746891 (DO).

Publisher Copyright:
© 2019 Federation of European Neuroscience Societies and John Wiley & Sons Ltd

Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.

Keywords

  • alcohol exposure
  • associative learning
  • decoding
  • electrophysiology
  • reward

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