Recovery of hibernating myocardium: What is the role of surgical revascularization?

Christopher T. Holley, Eric K. Long, Megan E. Lindsey, Edward O. McFalls, Rosemary F. Kelly

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


Myocardial responses to chronic ischemia represent a continuum of adaptations resulting, over time, in a stress-resistant phenotype. One such adaptation, hibernating myocardium (HM), has increased antioxidant capacity that protects against ischemia-induced oxidative stress. Studies have suggested that revascularization alone may not fully restore cardiac function, highlighting the need for targeted therapies to serve as adjuncts to the innate healing process following revascularization. In our review, we discuss current understanding of HM and the recovery process following surgical revascularization, focusing on animal models of HM to understand implications for human patients. doi: 10.1111/jocs.12477

Original languageEnglish (US)
Pages (from-to)224-231
Number of pages8
JournalJournal of Cardiac Surgery
Issue number2
StatePublished - Feb 1 2015

Bibliographical note

Publisher Copyright:
© 2014 Wiley Periodicals, Inc.


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