Recombination in adaptive mutation

Reuben S. Harris, Simonne Longerich, Susan M. Rosenberg

Research output: Contribution to journalArticlepeer-review

215 Scopus citations

Abstract

The genetic requirements for adaptive mutation in Escherichia coli parallel those for homologous recombination in the RecBCD pathway. Recombination- deficient recA and recB null mutant strains are deficient in adaptive reversion. A hyper-recombinagenic recD strain is hypermutable, and its hypermutation depends on functional recA and recB genes. Genes of subsidiary recombination systems are not required. These results indicate that the molecular mechanism by which adaptive mutation occurs includes recombination. No such association is seen for spontaneous mutation in growing cells.

Original languageEnglish (US)
Pages (from-to)258-260
Number of pages3
JournalScience
Volume264
Issue number5156
DOIs
StatePublished - Jan 1 1994

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