Recombination-dependent mutation in non-dividing cells

Susan M. Rosenberg; Reuben S. Harris; Simonne Longerich; Anne M. Galloway

doi:10.1016/0027-5107(95)00092-5

Recombination-dependent mutation in non-dividing cells

Susan M. Rosenberg, Reuben S. Harris, Simonne Longerich, Anne M. Galloway

Biochemistry, Molecular Biology, and Biophysics (CBS)

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Over the past 6 years an unexpected way of making mutations in bacteria has challenged concepts of the genetic mechanisms behind evolution. Mechanistic studies of these so called 'adaptive' mutations are revealing a novel molecular mechanism involving DNA double-strand breaks, genetic recombination, probable DNA polymerase errors, and the possible suspension of mismatch repair during the reversion of a lac frameshift mutation in Escherichia coli. The molecular details of this process are altering our understanding of how mutations form in non-dividing cells.

Original language	English (US)
Pages (from-to)	69-76
Number of pages	8
Journal	Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume	350
Issue number	1
DOIs	https://doi.org/10.1016/0027-5107(95)00092-5
State	Published - Feb 19 1996

Bibliographical note

Funding Information:
We thank G. Haljan, P.J. Hastings and H. Razavy for commentso n the manuscript.S upportedb y grants from Natural Sciences and Engineering Research Council of Canada (NSERC), Medical Research Council of Canada. and the Alberta Heritage Foundation for Medical Research (AHFMR). an AHFMR graduate studentship, NSERC graduate studentship, Walter H. Johns graduate studentship and Lionel McLeod fellowship to RSH. and an AHFMR postdoctoral fellowship to AMG. SMR is an Alberta Heritage Medical Scholar.

Keywords

Adaptive mutation
DNA double-strand break
Directed mutation
Escherichia coli
Mismatch repair
RecA
RecBCD
Recombination
Repent instability

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title = "Recombination-dependent mutation in non-dividing cells",

abstract = "Over the past 6 years an unexpected way of making mutations in bacteria has challenged concepts of the genetic mechanisms behind evolution. Mechanistic studies of these so called 'adaptive' mutations are revealing a novel molecular mechanism involving DNA double-strand breaks, genetic recombination, probable DNA polymerase errors, and the possible suspension of mismatch repair during the reversion of a lac frameshift mutation in Escherichia coli. The molecular details of this process are altering our understanding of how mutations form in non-dividing cells.",

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note = "Funding Information: We thank G. Haljan, P.J. Hastings and H. Razavy for commentso n the manuscript.S upportedb y grants from Natural Sciences and Engineering Research Council of Canada (NSERC), Medical Research Council of Canada. and the Alberta Heritage Foundation for Medical Research (AHFMR). an AHFMR graduate studentship, NSERC graduate studentship, Walter H. Johns graduate studentship and Lionel McLeod fellowship to RSH. and an AHFMR postdoctoral fellowship to AMG. SMR is an Alberta Heritage Medical Scholar.",

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AU - Harris, Reuben S.

AU - Longerich, Simonne

AU - Galloway, Anne M.

N1 - Funding Information: We thank G. Haljan, P.J. Hastings and H. Razavy for commentso n the manuscript.S upportedb y grants from Natural Sciences and Engineering Research Council of Canada (NSERC), Medical Research Council of Canada. and the Alberta Heritage Foundation for Medical Research (AHFMR). an AHFMR graduate studentship, NSERC graduate studentship, Walter H. Johns graduate studentship and Lionel McLeod fellowship to RSH. and an AHFMR postdoctoral fellowship to AMG. SMR is an Alberta Heritage Medical Scholar.

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Y1 - 1996/2/19

N2 - Over the past 6 years an unexpected way of making mutations in bacteria has challenged concepts of the genetic mechanisms behind evolution. Mechanistic studies of these so called 'adaptive' mutations are revealing a novel molecular mechanism involving DNA double-strand breaks, genetic recombination, probable DNA polymerase errors, and the possible suspension of mismatch repair during the reversion of a lac frameshift mutation in Escherichia coli. The molecular details of this process are altering our understanding of how mutations form in non-dividing cells.

AB - Over the past 6 years an unexpected way of making mutations in bacteria has challenged concepts of the genetic mechanisms behind evolution. Mechanistic studies of these so called 'adaptive' mutations are revealing a novel molecular mechanism involving DNA double-strand breaks, genetic recombination, probable DNA polymerase errors, and the possible suspension of mismatch repair during the reversion of a lac frameshift mutation in Escherichia coli. The molecular details of this process are altering our understanding of how mutations form in non-dividing cells.

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KW - DNA double-strand break

KW - Directed mutation

KW - Escherichia coli

KW - Mismatch repair

KW - RecA

KW - RecBCD

KW - Recombination

KW - Repent instability

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Recombination-dependent mutation in non-dividing cells

Abstract

Bibliographical note

Keywords

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