Recombination-based mechanisms for somatic hypermutation

Qingzhong Kong, Reuben S. Harris, Nancy Maizels

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

We review some experiments designed to test recombination-based mechanisms for somatic hypermutation in mice, particularly mechanisms involving templated mutation or gene conversion. As recombination and repair functions are highly conserved among prokaryotes and eukaryotes, pathways of mutation in microorganisms may prove relevant to the mechanism of somatic hypermutation. Escherichia coli initates a recombination-based pathway of mutation in response to environmental stimuli, and this 'adaptive' pathway of mutation has striking similarities with somatic hypermutation, as does a process of mutagenic repair that occurs at double-strand breaks in Saccharomyces cerevisiae. We present a model for recombination-based hypermutation of the immunoglobulin loci which could result in either templated or non-templated mutation.

Original languageEnglish (US)
Pages (from-to)67-76
Number of pages10
JournalImmunological Reviews
Volume162
DOIs
StatePublished - Apr 1998

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