Recombinant protein therapeutics from CHO Cells - 20 years and counting

Karthik P. Jayapal, Katie F. Wlaschin, Wei Shou Hu, Miranda G S Yap

Research output: Contribution to journalArticle

337 Scopus citations

Abstract

Recombinant protein therapy from Chinese Hamster Ovary (CHO) cell has brought significant improvement in the healthcare services. CHO cell continues to be used for recombinant protein therapy, as it is adaptable to various cell culture conditions and plasticity, to perform genetic alterations. Recombinant protein therapy continues to provide innovative and effective therapies for several refractory diseases. The protein therapy from CHO cells is being used for treating a variety of human diseases, including cancers and infertility. These proteins are synthesized by large-scale cultivation of genetically engineered cells, which contain artificially transfected genes encoding for the proteins for specific requirements. The proteins need to be synthesized in biologically active forms, for protein therapy to be effective.

Original languageEnglish (US)
Pages (from-to)40-47
Number of pages8
JournalChemical Engineering Progress
Volume103
Issue number10
StatePublished - Oct 2007

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    Jayapal, K. P., Wlaschin, K. F., Hu, W. S., & Yap, M. G. S. (2007). Recombinant protein therapeutics from CHO Cells - 20 years and counting. Chemical Engineering Progress, 103(10), 40-47.