Receptor usage and cell entry of porcine epidemic diarrhea coronavirus

Chang Liu; Jian Tang; Yuanmei Ma; Xueya Liang; Yang Yang; Guiqing Peng; Qianqian Qi; Shibo Jiang; Jianrong Li; Lanying Du; Fang Li

doi:10.1128/JVI.00430-15

Receptor usage and cell entry of porcine epidemic diarrhea coronavirus

Chang Liu
, Jian Tang
, Yuanmei Ma
, Xueya Liang
, Yang Yang
, Guiqing Peng
, Qianqian Qi
, Shibo Jiang
, Jianrong Li
, Lanying Du
, Fang Li

Research output: Contribution to journal › Article › peer-review

237 Scopus citations

Abstract

Porcine epidemic diarrhea coronavirus (PEDV) has significantly damaged America's pork industry. Here we investigate the receptor usage and cell entry of PEDV. PEDV recognizes protein receptor aminopeptidase N from pig and human and sugar coreceptor N-acetylneuraminic acid. Moreover, PEDV infects cells from pig, human, monkey, and bat. These results support the idea of bats as an evolutionary origin for PEDV, implicate PEDV as a potential threat to other species, and suggest antiviral strategies to control its spread.

Original language	English (US)
Pages (from-to)	6121-6125
Number of pages	5
Journal	Journal of virology
Volume	89
Issue number	11
DOIs	https://doi.org/10.1128/JVI.00430-15
State	Published - 2015

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Publisher Copyright:
© 2015, American Society for Microbiology.

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10.1128/JVI.00430-15

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title = "Receptor usage and cell entry of porcine epidemic diarrhea coronavirus",

abstract = "Porcine epidemic diarrhea coronavirus (PEDV) has significantly damaged America's pork industry. Here we investigate the receptor usage and cell entry of PEDV. PEDV recognizes protein receptor aminopeptidase N from pig and human and sugar coreceptor N-acetylneuraminic acid. Moreover, PEDV infects cells from pig, human, monkey, and bat. These results support the idea of bats as an evolutionary origin for PEDV, implicate PEDV as a potential threat to other species, and suggest antiviral strategies to control its spread.",

author = "Chang Liu and Jian Tang and Yuanmei Ma and Xueya Liang and Yang Yang and Guiqing Peng and Qianqian Qi and Shibo Jiang and Jianrong Li and Lanying Du and Fang Li",

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doi = "10.1128/JVI.00430-15",

language = "English (US)",

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TY - JOUR

T1 - Receptor usage and cell entry of porcine epidemic diarrhea coronavirus

AU - Liu, Chang

AU - Tang, Jian

AU - Ma, Yuanmei

AU - Liang, Xueya

AU - Yang, Yang

AU - Peng, Guiqing

AU - Qi, Qianqian

AU - Jiang, Shibo

AU - Li, Jianrong

AU - Du, Lanying

AU - Li, Fang

PY - 2015

Y1 - 2015

N2 - Porcine epidemic diarrhea coronavirus (PEDV) has significantly damaged America's pork industry. Here we investigate the receptor usage and cell entry of PEDV. PEDV recognizes protein receptor aminopeptidase N from pig and human and sugar coreceptor N-acetylneuraminic acid. Moreover, PEDV infects cells from pig, human, monkey, and bat. These results support the idea of bats as an evolutionary origin for PEDV, implicate PEDV as a potential threat to other species, and suggest antiviral strategies to control its spread.

AB - Porcine epidemic diarrhea coronavirus (PEDV) has significantly damaged America's pork industry. Here we investigate the receptor usage and cell entry of PEDV. PEDV recognizes protein receptor aminopeptidase N from pig and human and sugar coreceptor N-acetylneuraminic acid. Moreover, PEDV infects cells from pig, human, monkey, and bat. These results support the idea of bats as an evolutionary origin for PEDV, implicate PEDV as a potential threat to other species, and suggest antiviral strategies to control its spread.

UR - https://www.scopus.com/pages/publications/84929648712

UR - https://www.scopus.com/pages/publications/84929648712#tab=citedBy

U2 - 10.1128/JVI.00430-15

DO - 10.1128/JVI.00430-15

M3 - Article

C2 - 25787280

AN - SCOPUS:84929648712

SN - 0022-538X

VL - 89

SP - 6121

EP - 6125

JO - Journal of virology

JF - Journal of virology

IS - 11

ER -

Receptor usage and cell entry of porcine epidemic diarrhea coronavirus

Abstract

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