Receptor tyrosine kinases MET and RON as prognostic factors in diffuse large B-cell lymphoma patients receiving R-CHOP

Young Wha Koh, Hee Sang Hwang, Se Jin Jung, Chansik Park, Dok Hyun Yoon, Cheolwon Suh, Jooryung Huh

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15 Scopus citations

Abstract

Receptor tyrosine kinases MET and RON (MST1R) form non-covalent complexes on the cell surface, a critical step in tumor progression. A recent study suggested a prognostic role for MET expression in diffuse large B-cell lymphoma (DLBCL). The aim of this study was to examine the impact of MET and RON expression in uniformly treated DLBCL patients. The expression of MET and RON was retrospectively examined by immunohistochemistry in 120 DLBCL patients treated with rituximab combined with a CHOP regimen (cyclophosphamide, doxorubicin, vincristine, and prednisone). The median follow-up time was 42.5 months (range, 1-89 months). Thirty-two (26%) and 30 patients (25%) expressed MET or RON, respectively. Seventy-five patients (62.5%) were negative for both MET and RON (MET-RON-). MET negativity was associated with worse overall survival (P = 0.029). In multivariate analysis, negativity for both MET and RON (MET-RON-) was strongly associated with inferior overall survival (P = 0.008). Interestingly, the MET-RON- phenotype retained its prognostic impact after subgroup analysis according to the international prognostic index or by the cell of origin by immunohistochemical algorithm by Choi et al. This study suggests that the MET-RON- phenotype is an independent prognostic factor in DLBCL patients receiving R-CHOP, and may identify a subgroup of DLBCL patients who require more intensive therapy.

Original languageEnglish (US)
Pages (from-to)1245-1251
Number of pages7
JournalCancer Science
Volume104
Issue number9
DOIs
StatePublished - Sep 2013

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    Koh, Y. W., Hwang, H. S., Jung, S. J., Park, C., Yoon, D. H., Suh, C., & Huh, J. (2013). Receptor tyrosine kinases MET and RON as prognostic factors in diffuse large B-cell lymphoma patients receiving R-CHOP. Cancer Science, 104(9), 1245-1251. https://doi.org/10.1111/cas.12215