Receptor sensitivity: When T cells lose their sense of self

Kristin A. Hogquist; Timothy K. Starr; Stephen C. Jameson

doi:10.1016/S0960-9822(03)00161-1

Receptor sensitivity: When T cells lose their sense of self

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Abstract

The T-cell antigen receptor binds to self-MHC molecules with low affinity. Recent reports disagree as to whether this interaction sensitizes or desensitizes the receptor. Here we discuss how these findings might be reconciled.

Original language	English (US)
Pages (from-to)	R239-R241
Journal	Current Biology
Volume	13
Issue number	6
DOIs	https://doi.org/10.1016/S0960-9822(03)00161-1
State	Published - Mar 18 2003

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title = "Receptor sensitivity: When T cells lose their sense of self",

abstract = "The T-cell antigen receptor binds to self-MHC molecules with low affinity. Recent reports disagree as to whether this interaction sensitizes or desensitizes the receptor. Here we discuss how these findings might be reconciled.",

author = "Hogquist, \{Kristin A.\} and Starr, \{Timothy K.\} and Jameson, \{Stephen C.\}",

year = "2003",

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AU - Hogquist, Kristin A.

AU - Starr, Timothy K.

AU - Jameson, Stephen C.

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N2 - The T-cell antigen receptor binds to self-MHC molecules with low affinity. Recent reports disagree as to whether this interaction sensitizes or desensitizes the receptor. Here we discuss how these findings might be reconciled.

AB - The T-cell antigen receptor binds to self-MHC molecules with low affinity. Recent reports disagree as to whether this interaction sensitizes or desensitizes the receptor. Here we discuss how these findings might be reconciled.

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VL - 13

SP - R239-R241

JO - Current Biology

JF - Current Biology

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Receptor sensitivity: When T cells lose their sense of self

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