Recent studies of the pharmacokinetics of vancomycin

J. Rotschafer, K. Mead, K. Crossley

Research output: Contribution to journalArticlepeer-review

Abstract

Vancomycin is a bactericidal antistaphylococcal antibiotic made available for clinical usage in 1956. Following the introduction of the penicillinase-resistant penicillins a few years later, vancomycin became an uncommonly used second choice antibiotic for treatment of staphylococcal infection. In the last few years, probably as the result of outbreaks of infection caused by methicillin-resistant S. aureus, vancomycin has again been widely used in Europe and in North America. Because vancomycin rapidly fell into disuse following its introduction, only a few clinical studies of this antibiotic are available. Published information about the pharmacokinetics of vancomycin consists of small studies using the rather limited analytic techniques available 25 years ago. In this paper, we report some aspects of our recent studies of the pharmacokinetics of vancomycin.

Original languageEnglish (US)
Pages (from-to)773-776
Number of pages4
JournalZentralblatt fur Bakteriologie Mikrobiologie und Hygiene - Abt. 1 Orig. A
Volume251
Issue numberSuppl. 10
StatePublished - Jan 1 1981

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