Recent progress in and challenges in cellular therapy using NK cells for hematological malignancies

Junji Tanaka, Jeffrey S. Miller

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

NK cells have killing activity against leukemic cells and solid cancer cells that escape from T cell recognition because of the low expression level of HLA class I molecules. This characteristic feature of NK cell recognition of target cells in contrast to T cells provides a strategy to overcome tolerance in cancer and leukemia patients. A strong alloreactive NK cell-mediated anti-leukemia effect can be induced in haploidentical hematopoietic stem cell transplantation. Also, NK cells can be expanded by several methods for adoptive immunotherapy for hematological malignancies and other malignant diseases. We review the historical role of NK cells and recent approaches to enhance the functions of NK cells, including ex vivo expansion of autologous and allogenic NK cells, checkpoint receptor blockade, and the use of memory-like NK cells and CAR-NK cells, for treatment of hematological malignancies.

Original languageEnglish (US)
Article number100678
JournalBlood Reviews
Volume44
DOIs
StatePublished - Nov 2020

Bibliographical note

Funding Information:
We thank Ms. R. Tsuruya and Ms. A. Morishita for their assistance. This study was supported in part by a Grant-in-Aid from the Ministry of Health, Labor and Welfare of Japan , the Mitsubishi Foundation .

Funding Information:
We thank Ms. R. Tsuruya and Ms. A. Morishita for their assistance. This study was supported in part by a Grant-in-Aid from the Ministry of Health, Labor and Welfare of Japan, the Mitsubishi Foundation.

Publisher Copyright:
© 2020 Elsevier Ltd

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

Keywords

  • ADCC
  • BiKE
  • CAR-NK
  • Cellular therapy
  • KIR
  • NK cell
  • TriKE

PubMed: MeSH publication types

  • Journal Article
  • Review
  • Research Support, Non-U.S. Gov't

Fingerprint

Dive into the research topics of 'Recent progress in and challenges in cellular therapy using NK cells for hematological malignancies'. Together they form a unique fingerprint.

Cite this