Recent advances in host defense mechanisms/therapies against oral infectious diseases and consequences for systemic disease

S. L. Gaffen, M. C. Herzberg, M. A. Taubman, T. E. Van Dyke

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

The innate and adaptive immune systems are both crucial to oral disease mechanisms and their impact on systemic health status. Greater understanding of these interrelationships will yield opportunities to identify new therapeutic targets to modulate disease processes and/or increase host resistance to infectious or inflammatory insult. The topics addressed reflect the latest advances in our knowledge of the role of innate and adaptive immune systems and inflammatory mechanisms in infectious diseases affecting the oral cavity, including periodontitis and candidiasis. In addition, several potential links with systemic inflammatory conditions, such as cardiovascular disease, are explored. The findings elucidate some of the defense mechanisms utilized by host tissues, including the role of IL-17 in providing immunity to oral candidiasis, the antimicrobial defense of mucosal epithelial cells, and the pro-resolution effects of the natural inflammatory regulators, proresolvins and lipoxins. They also describe the role of immune cells in mediating pathologic bone resorption in periodontal disease. These insights highlight the potential for therapeutic benefit of immunomodulatory interventions that bolster or modulate host defense mechanisms in both oral and systemic disease. Among the promising new therapeutic approaches discussed here are epithelial cell gene therapy, passive immunization against immune cell targets, and the use of proresolvin agents.

Original languageEnglish (US)
Pages (from-to)30-37
Number of pages8
JournalAdvances in dental research
Volume26
Issue number1
DOIs
StatePublished - May 1 2014

Keywords

  • bacterial invasion
  • cytokines
  • fungal immunity
  • lipoxins
  • oropharyngeal candidiasis
  • periodontal bone resorption

Fingerprint Dive into the research topics of 'Recent advances in host defense mechanisms/therapies against oral infectious diseases and consequences for systemic disease'. Together they form a unique fingerprint.

Cite this