Abstract
Major advances in understanding cholesterol dynamics and the role that cholesterol plays in vascular disease have recently been made. The brain is an organ that is highly enriched in cholesterol, but progress toward understanding brain cholesterol dynamics has been relatively limited. This review examines recent contributions to the understanding of brain cholesterol dynamics, focusing on extracellular and intracellular lipid carrier proteins, membrane cholesterol domains, and emerging evidence linking an association between cholesterol dynamics and Alzheimer's disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 225-234 |
| Number of pages | 10 |
| Journal | Lipids |
| Volume | 34 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1999 |
Bibliographical note
Funding Information:This work was supported in part by grants from the National Institutes of Health (AA-07292, AG-11056 to W.G.W; AA-10806 to N.A.A.; GM-31651 to F.S.) and the Medical Research Program of the Department of Veterans Affairs (to W.G.W).