TY - JOUR
T1 - Recent advances in brain cholesterol dynamics
T2 - Transport, domains, and Alzheimer's disease
AU - Wood, W. Gibson
AU - Schroeder, Friedhelm
AU - Avdulov, Nicolai A.
AU - Chochina, Svetlana V.
AU - Igbavboa, Urule
PY - 1999/1/1
Y1 - 1999/1/1
N2 - Major advances in understanding cholesterol dynamics and the role that cholesterol plays in vascular disease have recently been made. The brain is an organ that is highly enriched in cholesterol, but progress toward understanding brain cholesterol dynamics has been relatively limited. This review examines recent contributions to the understanding of brain cholesterol dynamics, focusing on extracellular and intracellular lipid carrier proteins, membrane cholesterol domains, and emerging evidence linking an association between cholesterol dynamics and Alzheimer's disease.
AB - Major advances in understanding cholesterol dynamics and the role that cholesterol plays in vascular disease have recently been made. The brain is an organ that is highly enriched in cholesterol, but progress toward understanding brain cholesterol dynamics has been relatively limited. This review examines recent contributions to the understanding of brain cholesterol dynamics, focusing on extracellular and intracellular lipid carrier proteins, membrane cholesterol domains, and emerging evidence linking an association between cholesterol dynamics and Alzheimer's disease.
UR - http://www.scopus.com/inward/record.url?scp=0032925484&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032925484&partnerID=8YFLogxK
U2 - 10.1007/s11745-999-0357-9
DO - 10.1007/s11745-999-0357-9
M3 - Article
C2 - 10230715
AN - SCOPUS:0032925484
VL - 34
SP - 225
EP - 234
JO - Lipids
JF - Lipids
SN - 0024-4201
IS - 3
ER -