Recent advances in AIDS-related cryptococcal meningitis treatment with an emphasis on resource limited settings

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

Introduction: Recent advances in the treatment and prevention of cryptococcal meningitis have the potential to decrease AIDS-related deaths. Areas covered: Targeted screening for asymptomatic cryptococcal antigenemia in persons with AIDS is a cost effective method for reducing early mortality in patients on antiretroviral therapy. For persons with symptomatic cryptococcal meningitis, optimal initial management with amphotericin and flucytosine improves survival compared to alternative therapies; however, amphotsericin is difficult to administer and flucytosine has not been available in middle or low income countries, where cryptococcal meningitis is most prevalent. Expert commentary: Improved care for cryptococcal meningitis patients in resource-limited settings is possible, and new treatment possibilities are emerging.

Original languageEnglish (US)
Pages (from-to)331-340
Number of pages10
JournalExpert review of anti-infective therapy
Volume15
Issue number4
DOIs
StatePublished - Apr 3 2017

Bibliographical note

Funding Information:
The authors are supported by the National Institutes of Health, National Institute of Allergy and Infectious Diseases and the Fogarty International Center [R01NS086312, T32AI055433, R25TW009345].

Publisher Copyright:
© 2017 Informa UK Limited, trading as Taylor & Francis Group.

Keywords

  • AIDS
  • CM-IRIS
  • HIV
  • antifungal therapy
  • antiretroviral therapy
  • cryptococcal meningitis
  • immune reconstitution inflammatory syndrome
  • review
  • sertraline

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