Reassessing medical risk in living kidney donors

Robert S. Gaston, Vineeta Kumar, Arthur J. Matas

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


The short- and long-term effects of unilateral nephrectomy on living donors have been important considerations for 60 years. Short-term risk is well established (0.03% mortality and <1% risk of major morbidity), but characterization of long-term risk is evolving. Relative to the general population, risk of mortality, ESRD, hypertension, proteinuria, and cardiovascular disease is comparable or lower. However, new studies comparing previous donors with equally healthy controls indicate increased risk of metabolic derangements (particularly involving calcium homeostasis), renal failure, and possibly, mortality. We discuss how these results should be interpreted and their influence on the practice of living donor kidney transplantation.

Original languageEnglish (US)
Pages (from-to)1017-1019
Number of pages3
JournalJournal of the American Society of Nephrology
Issue number5
StatePublished - May 1 2015

Bibliographical note

Publisher Copyright:
Copyright © 2015 by the American Society of Nephrology.


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