Reanalysis of coreceptor tropism in HIV-1-infected adults using a phenotypic assay with enhanced sensitivity

Timothy J. Wilkin; Mathew Bidwell Goetz; Robert Leduc; Gail Skowron; Zhaohui Su; Ellen S. Chan; Jayyant Heera; Doug Chapman; John Spritzler; Jacqueline D. Reeves; Roy M. Gulick; Eoin Coakley

doi:10.1093/cid/cir072

Reanalysis of coreceptor tropism in HIV-1-infected adults using a phenotypic assay with enhanced sensitivity

Timothy J. Wilkin
, Mathew Bidwell Goetz
, Robert Leduc
, Gail Skowron
, Zhaohui Su
, Ellen S. Chan
, Jayyant Heera
, Doug Chapman
, John Spritzler
, Jacqueline D. Reeves
, Roy M. Gulick
, Eoin Coakley

Biostatistics

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

The enhanced-sensitivity Trofile assay (TF-ES; Monogram Biosciences) was used to retest coreceptor tropism samples from 4 different cohorts of HIV-1-infected patients. Nine percent to 26% of patients with CCR5-tropic virus by the original Trofile assay had CXCR4-using virus by TF-ES. Lower CD4 cell counts were associated with CXCR4-using virus in all cohorts.

Original language	English (US)
Pages (from-to)	925-928
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	52
Issue number	7
DOIs	https://doi.org/10.1093/cid/cir072
State	Published - Apr 1 2011

Bibliographical note

Funding Information:
Financial Support. The CPCRA and INSIGHT networks are funded by the National Institutes of Health (U01 AI-42170, U01 AI-46362, U01 AI-68641). The ACTG is funded by the National Institutes of Health (U01 AI-68636 and AI-68634 [Statistical and Data Analysis Center]). Other grants that funded coauthors include K23 AI55038 (to T.J.W.), K24 AI51966 (to R.M.G.), AI-69419 (Cornell Clinical Trials Unit), RR024996 (Cornell CTSC), and AI-46381 (Miriam Hospital Clinical Research Site). Monogram Biosciences received an SBIR grant from the National Institutes of Health (R44AI050321).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1093/cid/cir072

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@article{0934adc1564a4596ab56e5ced728a955,

title = "Reanalysis of coreceptor tropism in HIV-1-infected adults using a phenotypic assay with enhanced sensitivity",

abstract = "The enhanced-sensitivity Trofile assay (TF-ES; Monogram Biosciences) was used to retest coreceptor tropism samples from 4 different cohorts of HIV-1-infected patients. Nine percent to 26\% of patients with CCR5-tropic virus by the original Trofile assay had CXCR4-using virus by TF-ES. Lower CD4 cell counts were associated with CXCR4-using virus in all cohorts.",

author = "Wilkin, \{Timothy J.\} and Goetz, \{Mathew Bidwell\} and Robert Leduc and Gail Skowron and Zhaohui Su and Chan, \{Ellen S.\} and Jayyant Heera and Doug Chapman and John Spritzler and Reeves, \{Jacqueline D.\} and Gulick, \{Roy M.\} and Eoin Coakley",

note = "Funding Information: Financial Support. The CPCRA and INSIGHT networks are funded by the National Institutes of Health (U01 AI-42170, U01 AI-46362, U01 AI-68641). The ACTG is funded by the National Institutes of Health (U01 AI-68636 and AI-68634 [Statistical and Data Analysis Center]). Other grants that funded coauthors include K23 AI55038 (to T.J.W.), K24 AI51966 (to R.M.G.), AI-69419 (Cornell Clinical Trials Unit), RR024996 (Cornell CTSC), and AI-46381 (Miriam Hospital Clinical Research Site). Monogram Biosciences received an SBIR grant from the National Institutes of Health (R44AI050321).",

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doi = "10.1093/cid/cir072",

language = "English (US)",

volume = "52",

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T1 - Reanalysis of coreceptor tropism in HIV-1-infected adults using a phenotypic assay with enhanced sensitivity

AU - Wilkin, Timothy J.

AU - Goetz, Mathew Bidwell

AU - Leduc, Robert

AU - Skowron, Gail

AU - Su, Zhaohui

AU - Chan, Ellen S.

AU - Heera, Jayyant

AU - Chapman, Doug

AU - Spritzler, John

AU - Reeves, Jacqueline D.

AU - Gulick, Roy M.

AU - Coakley, Eoin

N1 - Funding Information: Financial Support. The CPCRA and INSIGHT networks are funded by the National Institutes of Health (U01 AI-42170, U01 AI-46362, U01 AI-68641). The ACTG is funded by the National Institutes of Health (U01 AI-68636 and AI-68634 [Statistical and Data Analysis Center]). Other grants that funded coauthors include K23 AI55038 (to T.J.W.), K24 AI51966 (to R.M.G.), AI-69419 (Cornell Clinical Trials Unit), RR024996 (Cornell CTSC), and AI-46381 (Miriam Hospital Clinical Research Site). Monogram Biosciences received an SBIR grant from the National Institutes of Health (R44AI050321).

PY - 2011/4/1

Y1 - 2011/4/1

N2 - The enhanced-sensitivity Trofile assay (TF-ES; Monogram Biosciences) was used to retest coreceptor tropism samples from 4 different cohorts of HIV-1-infected patients. Nine percent to 26% of patients with CCR5-tropic virus by the original Trofile assay had CXCR4-using virus by TF-ES. Lower CD4 cell counts were associated with CXCR4-using virus in all cohorts.

AB - The enhanced-sensitivity Trofile assay (TF-ES; Monogram Biosciences) was used to retest coreceptor tropism samples from 4 different cohorts of HIV-1-infected patients. Nine percent to 26% of patients with CCR5-tropic virus by the original Trofile assay had CXCR4-using virus by TF-ES. Lower CD4 cell counts were associated with CXCR4-using virus in all cohorts.

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ER -

Reanalysis of coreceptor tropism in HIV-1-infected adults using a phenotypic assay with enhanced sensitivity

Abstract

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UN SDGs

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