Real-time monitoring of thermal and mechanical tissue response to modulated phased-array HIFU beams in vivo

Dalong Liu, John R. Ballard, Alyona Haritonova, Jeungwan Choi, John C Bischof, Emad S Ebbini

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

An integrated system employing real-time ultrasound thermography and strain imaging in monitoring tissue response to phased-array heating patterns has been developed. The imaging system is implemented on a commercially available scanner (SonixRP) at frame rates > 500 fps with limited frame sizes covering the vicinity of the HIFU focal spot. These frame rates are sufficient to capture tissue motion and deformation even in the vicinity of large arteries. With the high temporal and spatial resolution of our strain imaging system, we are able to capture and separate tissue strains due to natural motion (breathing and pulsation) from HIFU induced strains (thermal and mechanical). We have collected in vivo strain imaging during sub-therapeutic and therapeutic HIFU exposure in swine and rat model. A 3.5-MHz phased array was used to generate sinusoidally-modulated pHIFU beams at different intensity levels and durations near blood vessels of different sizes (e.g. femoral in the swine and rat models). The results show that our approach is capable of characterizing the thermal and mechanical tissue response to sub-therapeutic pHIFU beam. For therapeutic pHIFU beams, the approach is still capable of localizing the therapeutic beam, but the results at the focal spot are complicated by bubble generation.

Original languageEnglish (US)
Title of host publication11th International Symposium on Therapeutic Ultrasound
Pages227-232
Number of pages6
DOIs
StatePublished - Dec 1 2012
Event11th International Symposium on Therapeutic Ultrasound, ISTU 2011 - New York, NY, United States
Duration: Apr 11 2011Apr 13 2011

Publication series

NameAIP Conference Proceedings
Volume1481
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Other

Other11th International Symposium on Therapeutic Ultrasound, ISTU 2011
Country/TerritoryUnited States
CityNew York, NY
Period4/11/114/13/11

Keywords

  • HIFU
  • In vivo
  • Phased-array
  • Thermography

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