Abstract
Cardiac restitution is the shortening of the action potential duration with an increase in the heart rate. A shorter action potential duration enables a longer diastolic interval which ensures that the heart gets adequate time to refill with blood. At higher rates however, restitution becomes steep and thus, can lead to unstable electrical activity (alternans) in the heart, leading to fatal cardiac rhythms. It has been proposed that maintaining a shallow slope of cardiac restitution could have potentially anti-arrhythmic effects. Previous studies involved the control of action potential duration (APD) or diastolic interval (DI) in isolated tissue samples based on the feedback from single microelectrode recordings. This limited the spatial resolution of the feedback system. Here, we aimed to develop a real time feedback control system that enabled the detection of APDs from various single pixels based on optical mapping recordings. Stimuli were applied after a predefined fixed DI after detection of an APD. We validated our algorithm using optical mapping movies from an ex-vivo rabbit heart. Thus, we provide an optical mapping based approach for the control of cardiac restitution and a potential means to validate its anti-arrhythmic effects.
| Original language | English (US) |
|---|---|
| Title of host publication | 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015 |
| Publisher | Institute of Electrical and Electronics Engineers Inc. |
| Pages | 5920-5923 |
| Number of pages | 4 |
| Volume | 2015-November |
| ISBN (Electronic) | 9781424492718 |
| DOIs | |
| State | Published - Nov 4 2015 |
| Event | 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015 - Milan, Italy Duration: Aug 25 2015 → Aug 29 2015 |
Other
| Other | 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015 |
|---|---|
| Country | Italy |
| City | Milan |
| Period | 8/25/15 → 8/29/15 |
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Real-time feedback based control of cardiac restitution using optical mapping. / Kulkarni, Kanchan; Talkachova, Alena.
2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015. Vol. 2015-November Institute of Electrical and Electronics Engineers Inc., 2015. p. 5920-5923 7319739.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Real-time feedback based control of cardiac restitution using optical mapping
AU - Kulkarni, Kanchan
AU - Talkachova, Alena
PY - 2015/11/4
Y1 - 2015/11/4
N2 - Cardiac restitution is the shortening of the action potential duration with an increase in the heart rate. A shorter action potential duration enables a longer diastolic interval which ensures that the heart gets adequate time to refill with blood. At higher rates however, restitution becomes steep and thus, can lead to unstable electrical activity (alternans) in the heart, leading to fatal cardiac rhythms. It has been proposed that maintaining a shallow slope of cardiac restitution could have potentially anti-arrhythmic effects. Previous studies involved the control of action potential duration (APD) or diastolic interval (DI) in isolated tissue samples based on the feedback from single microelectrode recordings. This limited the spatial resolution of the feedback system. Here, we aimed to develop a real time feedback control system that enabled the detection of APDs from various single pixels based on optical mapping recordings. Stimuli were applied after a predefined fixed DI after detection of an APD. We validated our algorithm using optical mapping movies from an ex-vivo rabbit heart. Thus, we provide an optical mapping based approach for the control of cardiac restitution and a potential means to validate its anti-arrhythmic effects.
AB - Cardiac restitution is the shortening of the action potential duration with an increase in the heart rate. A shorter action potential duration enables a longer diastolic interval which ensures that the heart gets adequate time to refill with blood. At higher rates however, restitution becomes steep and thus, can lead to unstable electrical activity (alternans) in the heart, leading to fatal cardiac rhythms. It has been proposed that maintaining a shallow slope of cardiac restitution could have potentially anti-arrhythmic effects. Previous studies involved the control of action potential duration (APD) or diastolic interval (DI) in isolated tissue samples based on the feedback from single microelectrode recordings. This limited the spatial resolution of the feedback system. Here, we aimed to develop a real time feedback control system that enabled the detection of APDs from various single pixels based on optical mapping recordings. Stimuli were applied after a predefined fixed DI after detection of an APD. We validated our algorithm using optical mapping movies from an ex-vivo rabbit heart. Thus, we provide an optical mapping based approach for the control of cardiac restitution and a potential means to validate its anti-arrhythmic effects.
UR - http://www.scopus.com/inward/record.url?scp=84953266685&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84953266685&partnerID=8YFLogxK
U2 - 10.1109/EMBC.2015.7319739
DO - 10.1109/EMBC.2015.7319739
M3 - Conference contribution
C2 - 26737639
AN - SCOPUS:84953266685
VL - 2015-November
SP - 5920
EP - 5923
BT - 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015
PB - Institute of Electrical and Electronics Engineers Inc.
ER -