Reactive extraction of penicillin G in hollow-fiber and hollow-fiber fabric modules

Chuanfang Yang, E. L. Cussler

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


Penicillin G (Pen G) can be rapidly extracted in hollow-fiber liquid- liquid contactors using N-lauryl-N-trialkylmethylamine (Amberlite LA-2) as the extractant. n-Butylacetate is much better than decanol as a diluent for such an extraction, although decanol can give a partition coefficient four times larger. The overall mass transfer coefficient found is a function of aqueous flow on the lumen side of the fiber, and is less dependent on shell- side flow. In backextraction, the overall mass transfer coefficient determined is only one tenth that of the forward extraction, primarily because the hydrophobic hollow fibers used have a high mass transfer resistance under these conditions. The mass transfer experiments show that hollow-fiber extraction of Pen G is competitive with centrifugal extraction. The prospects for extraction of other fermentation products with hollow fibers can be estimated based on the present study. (C) 2000 John Wiley and Sons, Inc.

Original languageEnglish (US)
Pages (from-to)66-73
Number of pages8
JournalBiotechnology and Bioengineering
Issue number1
StatePublished - Jul 5 2000


  • Extraction
  • Hollow fibers
  • Mass transfer
  • Penicillin G


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