Reaction titration: A convenient method for titering reactive hydride agents (Red-Al, LiAlH4, DIBALH, L-selectride, NaH, and KH) by No-D NMR spectroscopy

Thomas R. Hoye, Andrew W. Aspaas, Brian M. Eklov, Troy D. Ryba

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

(Figure Presented) The concentration of reactive metal hydride (Met-H) reducing agents can be determined (in ≤20 min) using No-D NMR spectroscopy. The method involves (i) reacting Met-H with an excess of p-methoxybenzaldehyde, (ii) quenching with excess acetic acid, (iii) recording the No-D NMR spectrum of this homogeneous mixture, and (iv) deducing the concentration of Met-H from the % conversion (as measured by integration). By a conceptually related method, the titer of the basic alkali metal hydrides KH and NaH can also be determined.

Original languageEnglish (US)
Pages (from-to)2205-2208
Number of pages4
JournalOrganic Letters
Volume7
Issue number11
DOIs
StatePublished - May 26 2005

Fingerprint Dive into the research topics of 'Reaction titration: A convenient method for titering reactive hydride agents (Red-Al, LiAlH<sub>4</sub>, DIBALH, L-selectride, NaH, and KH) by No-D NMR spectroscopy'. Together they form a unique fingerprint.

  • Cite this